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Antimicrobial and Antioxidant Activities of Pycnocycla spinosa Extracts

BACKGROUND: Pycnocycla spinosa (P. spinosa) a member of the Umbelliferae family is traditionally used for treatment of different ailments. OBJECTIVES: This study aimed to evaluate the total phenolic and flavonoid content of P. spinosa extracts (methanol, ethanol and aqueous) and their antioxidant an...

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Autores principales: Mahboubi, Mohaddese, Taghizadeh, Mohsen, Kazempour, Nastaran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: DOCS 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165177/
https://www.ncbi.nlm.nih.gov/pubmed/25237641
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author Mahboubi, Mohaddese
Taghizadeh, Mohsen
Kazempour, Nastaran
author_facet Mahboubi, Mohaddese
Taghizadeh, Mohsen
Kazempour, Nastaran
author_sort Mahboubi, Mohaddese
collection PubMed
description BACKGROUND: Pycnocycla spinosa (P. spinosa) a member of the Umbelliferae family is traditionally used for treatment of different ailments. OBJECTIVES: This study aimed to evaluate the total phenolic and flavonoid content of P. spinosa extracts (methanol, ethanol and aqueous) and their antioxidant and antimicrobial effects. MATERIALS AND METHODS: The antimicrobial activity of different extracts of P. spinosa was evaluated using micro broth dilution. Total phenolic and flavonoid contents were measured. Their antioxidant effect was evaluated using DPPH assay and β-carotene linoleic acid test. RESULTS: P. spinosa ethanol extract with higher-level phenolic and flavonoid contents showed the highest antioxidant and antimicrobial effects, in comparison with the other extracts. Bacillus sp. and Streptococcus sp. showed higher sensitivity to P. spinosa ethanol extract. CONCLUSIONS: P. spinosa ethanol extract can be used as a mouthwash for treatment of the oral infections. More clinical and toxicological studies are required for providing its efficacy.
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spelling pubmed-41651772014-09-18 Antimicrobial and Antioxidant Activities of Pycnocycla spinosa Extracts Mahboubi, Mohaddese Taghizadeh, Mohsen Kazempour, Nastaran Jundishapur J Nat Pharm Prod Research Article BACKGROUND: Pycnocycla spinosa (P. spinosa) a member of the Umbelliferae family is traditionally used for treatment of different ailments. OBJECTIVES: This study aimed to evaluate the total phenolic and flavonoid content of P. spinosa extracts (methanol, ethanol and aqueous) and their antioxidant and antimicrobial effects. MATERIALS AND METHODS: The antimicrobial activity of different extracts of P. spinosa was evaluated using micro broth dilution. Total phenolic and flavonoid contents were measured. Their antioxidant effect was evaluated using DPPH assay and β-carotene linoleic acid test. RESULTS: P. spinosa ethanol extract with higher-level phenolic and flavonoid contents showed the highest antioxidant and antimicrobial effects, in comparison with the other extracts. Bacillus sp. and Streptococcus sp. showed higher sensitivity to P. spinosa ethanol extract. CONCLUSIONS: P. spinosa ethanol extract can be used as a mouthwash for treatment of the oral infections. More clinical and toxicological studies are required for providing its efficacy. DOCS 2014-06-22 /pmc/articles/PMC4165177/ /pubmed/25237641 Text en Copyright © 2014, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences; Published by DOCS. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mahboubi, Mohaddese
Taghizadeh, Mohsen
Kazempour, Nastaran
Antimicrobial and Antioxidant Activities of Pycnocycla spinosa Extracts
title Antimicrobial and Antioxidant Activities of Pycnocycla spinosa Extracts
title_full Antimicrobial and Antioxidant Activities of Pycnocycla spinosa Extracts
title_fullStr Antimicrobial and Antioxidant Activities of Pycnocycla spinosa Extracts
title_full_unstemmed Antimicrobial and Antioxidant Activities of Pycnocycla spinosa Extracts
title_short Antimicrobial and Antioxidant Activities of Pycnocycla spinosa Extracts
title_sort antimicrobial and antioxidant activities of pycnocycla spinosa extracts
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165177/
https://www.ncbi.nlm.nih.gov/pubmed/25237641
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