MethylPurify: tumor purity deconvolution and differential methylation detection from single tumor DNA methylomes

We propose a statistical algorithm MethylPurify that uses regions with bisulfite reads showing discordant methylation levels to infer tumor purity from tumor samples alone. MethylPurify can identify differentially methylated regions (DMRs) from individual tumor methylome samples, without genomic var...

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Detalles Bibliográficos
Autores principales: Zheng, Xiaoqi, Zhao, Qian, Wu, Hua-Jun, Li, Wei, Wang, Haiyun, Meyer, Clifford A, Qin, Qian Alvin, Xu, Han, Zang, Chongzhi, Jiang, Peng, Li, Fuqiang, Hou, Yong, He, Jianxing, Wang, Jun, Zhang, Peng, Zhang, Yong, Liu, Xiaole Shirley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165374/
https://www.ncbi.nlm.nih.gov/pubmed/25103624
http://dx.doi.org/10.1186/s13059-014-0419-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165374/
https://www.ncbi.nlm.nih.gov/pubmed/25103624
http://dx.doi.org/10.1186/s13059-014-0419-x

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