Synthesis of Acid-Labile PEG and PEG-Doxorubicin-Conjugate Nanoparticles via Brush-First ROMP

[Image: see text] A panel of acid-labile bis-norbornene cross-linkers was synthesized and evaluated for the formation of acid-degradable brush-arm star polymers (BASPs) via the brush-first ring-opening metathesis polymerization (ROMP) method. An acetal-based cross-linker was identified that, when em...

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Autores principales: Gao, Angela X., Liao, Longyan, Johnson, Jeremiah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165536/
https://www.ncbi.nlm.nih.gov/pubmed/25243099
http://dx.doi.org/10.1021/mz5004097
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author Gao, Angela X.
Liao, Longyan
Johnson, Jeremiah A.
author_facet Gao, Angela X.
Liao, Longyan
Johnson, Jeremiah A.
author_sort Gao, Angela X.
collection PubMed
description [Image: see text] A panel of acid-labile bis-norbornene cross-linkers was synthesized and evaluated for the formation of acid-degradable brush-arm star polymers (BASPs) via the brush-first ring-opening metathesis polymerization (ROMP) method. An acetal-based cross-linker was identified that, when employed in conjunction with a poly(ethylene glycol) (PEG) macromonomer, provided highly controlled BASP formation reactions. A combination of this new cross-linker with a novel doxorubicin (DOX)-branch-PEG macromonomer provided BASPs that simultaneously degrade and release cytotoxic DOX in vitro.
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spelling pubmed-41655362015-08-13 Synthesis of Acid-Labile PEG and PEG-Doxorubicin-Conjugate Nanoparticles via Brush-First ROMP Gao, Angela X. Liao, Longyan Johnson, Jeremiah A. ACS Macro Lett [Image: see text] A panel of acid-labile bis-norbornene cross-linkers was synthesized and evaluated for the formation of acid-degradable brush-arm star polymers (BASPs) via the brush-first ring-opening metathesis polymerization (ROMP) method. An acetal-based cross-linker was identified that, when employed in conjunction with a poly(ethylene glycol) (PEG) macromonomer, provided highly controlled BASP formation reactions. A combination of this new cross-linker with a novel doxorubicin (DOX)-branch-PEG macromonomer provided BASPs that simultaneously degrade and release cytotoxic DOX in vitro. American Chemical Society 2014-08-13 2014-09-16 /pmc/articles/PMC4165536/ /pubmed/25243099 http://dx.doi.org/10.1021/mz5004097 Text en Copyright © 2014 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html)
spellingShingle Gao, Angela X.
Liao, Longyan
Johnson, Jeremiah A.
Synthesis of Acid-Labile PEG and PEG-Doxorubicin-Conjugate Nanoparticles via Brush-First ROMP
title Synthesis of Acid-Labile PEG and PEG-Doxorubicin-Conjugate Nanoparticles via Brush-First ROMP
title_full Synthesis of Acid-Labile PEG and PEG-Doxorubicin-Conjugate Nanoparticles via Brush-First ROMP
title_fullStr Synthesis of Acid-Labile PEG and PEG-Doxorubicin-Conjugate Nanoparticles via Brush-First ROMP
title_full_unstemmed Synthesis of Acid-Labile PEG and PEG-Doxorubicin-Conjugate Nanoparticles via Brush-First ROMP
title_short Synthesis of Acid-Labile PEG and PEG-Doxorubicin-Conjugate Nanoparticles via Brush-First ROMP
title_sort synthesis of acid-labile peg and peg-doxorubicin-conjugate nanoparticles via brush-first romp
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165536/
https://www.ncbi.nlm.nih.gov/pubmed/25243099
http://dx.doi.org/10.1021/mz5004097
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