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Impact of the Prolymphangiogenic Crosstalk in the Tumor Microenvironment on Lymphatic Cancer Metastasis
Lymphangiogenesis is a very early step in lymphatic metastasis. It is regulated and promoted not only by the tumor cells themselves, but also by cells of the tumor microenvironment, including cancer associated fibroblasts, mesenchymal stem cells, dendritic cells, or macrophages. Even the extracellul...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165560/ https://www.ncbi.nlm.nih.gov/pubmed/25254213 http://dx.doi.org/10.1155/2014/639058 |
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author | Schlereth, Simona L. Refaian, Nasrin Iden, Sandra Cursiefen, Claus Heindl, Ludwig M. |
author_facet | Schlereth, Simona L. Refaian, Nasrin Iden, Sandra Cursiefen, Claus Heindl, Ludwig M. |
author_sort | Schlereth, Simona L. |
collection | PubMed |
description | Lymphangiogenesis is a very early step in lymphatic metastasis. It is regulated and promoted not only by the tumor cells themselves, but also by cells of the tumor microenvironment, including cancer associated fibroblasts, mesenchymal stem cells, dendritic cells, or macrophages. Even the extracellular matrix as well as cytokines and growth factors are involved in the process of lymphangiogenesis and metastasis. The cellular and noncellular components influence each other and can be influenced by the tumor cells. The knowledge about mechanisms behind lymphangiogenesis in the tumor microenvironmental crosstalk is growing and offers starting points for new therapeutic approaches. |
format | Online Article Text |
id | pubmed-4165560 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41655602014-09-24 Impact of the Prolymphangiogenic Crosstalk in the Tumor Microenvironment on Lymphatic Cancer Metastasis Schlereth, Simona L. Refaian, Nasrin Iden, Sandra Cursiefen, Claus Heindl, Ludwig M. Biomed Res Int Review Article Lymphangiogenesis is a very early step in lymphatic metastasis. It is regulated and promoted not only by the tumor cells themselves, but also by cells of the tumor microenvironment, including cancer associated fibroblasts, mesenchymal stem cells, dendritic cells, or macrophages. Even the extracellular matrix as well as cytokines and growth factors are involved in the process of lymphangiogenesis and metastasis. The cellular and noncellular components influence each other and can be influenced by the tumor cells. The knowledge about mechanisms behind lymphangiogenesis in the tumor microenvironmental crosstalk is growing and offers starting points for new therapeutic approaches. Hindawi Publishing Corporation 2014 2014-09-01 /pmc/articles/PMC4165560/ /pubmed/25254213 http://dx.doi.org/10.1155/2014/639058 Text en Copyright © 2014 Simona L. Schlereth et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Schlereth, Simona L. Refaian, Nasrin Iden, Sandra Cursiefen, Claus Heindl, Ludwig M. Impact of the Prolymphangiogenic Crosstalk in the Tumor Microenvironment on Lymphatic Cancer Metastasis |
title | Impact of the Prolymphangiogenic Crosstalk in the Tumor Microenvironment on Lymphatic Cancer Metastasis |
title_full | Impact of the Prolymphangiogenic Crosstalk in the Tumor Microenvironment on Lymphatic Cancer Metastasis |
title_fullStr | Impact of the Prolymphangiogenic Crosstalk in the Tumor Microenvironment on Lymphatic Cancer Metastasis |
title_full_unstemmed | Impact of the Prolymphangiogenic Crosstalk in the Tumor Microenvironment on Lymphatic Cancer Metastasis |
title_short | Impact of the Prolymphangiogenic Crosstalk in the Tumor Microenvironment on Lymphatic Cancer Metastasis |
title_sort | impact of the prolymphangiogenic crosstalk in the tumor microenvironment on lymphatic cancer metastasis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165560/ https://www.ncbi.nlm.nih.gov/pubmed/25254213 http://dx.doi.org/10.1155/2014/639058 |
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