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Mitochondrial localization of the OAS1 p46 isoform associated with a common single nucleotide polymorphism
BACKGROUND: The expression of 2′-5′-Oligoadenylate synthetases (OASs) is induced by type 1 Interferons (IFNs) in response to viral infection. The OAS proteins have a unique ability to produce 2′-5′ Oligoadenylates, which bind and activate the ribonuclease RNase L. The RNase L degrades cellular RNAs...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165621/ https://www.ncbi.nlm.nih.gov/pubmed/25205466 http://dx.doi.org/10.1186/1471-2121-15-33 |