Establishment of a novel CCR5 and CXCR4 expressing CD4(+ )cell line which is highly sensitive to HIV and suitable for high-throughput evaluation of CCR5 and CXCR4 antagonists

BACKGROUND: CCR5 and CXCR4 are the two main coreceptors essential for HIV entry. Therefore, these chemokine receptors have become important targets in the search for anti-HIV agents. Here, we describe the establishment of a novel CD4(+ )cell line, U87.CD4.CCR5.CXCR4, stably expressing both CCR5 and...

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Detalles Bibliográficos
Autores principales: Princen, Katrien, Hatse, Sigrid, Vermeire, Kurt, De Clercq, Erik, Schols, Dominique
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC416571/
https://www.ncbi.nlm.nih.gov/pubmed/15169555
http://dx.doi.org/10.1186/1742-4690-1-2

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