The Role of MicroRNAs in Diabetic Nephropathy

Diabetic nephropathy (DN), as one of the chronic complications of diabetes, is the major cause of end-stage renal disease. However, the pathogenesis of this disease is not fully understood. In recent years, research on microRNAs (miRNAs) has become a hotspot because of their critical role in regulat...

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Autores principales: Wu, Hao, Kong, Lili, Zhou, Shanshan, Cui, Wenpeng, Xu, Feng, Luo, Manyu, Li, Xiangqi, Tan, Yi, Miao, Lining
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165734/
https://www.ncbi.nlm.nih.gov/pubmed/25258717
http://dx.doi.org/10.1155/2014/920134
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author Wu, Hao
Kong, Lili
Zhou, Shanshan
Cui, Wenpeng
Xu, Feng
Luo, Manyu
Li, Xiangqi
Tan, Yi
Miao, Lining
author_facet Wu, Hao
Kong, Lili
Zhou, Shanshan
Cui, Wenpeng
Xu, Feng
Luo, Manyu
Li, Xiangqi
Tan, Yi
Miao, Lining
author_sort Wu, Hao
collection PubMed
description Diabetic nephropathy (DN), as one of the chronic complications of diabetes, is the major cause of end-stage renal disease. However, the pathogenesis of this disease is not fully understood. In recent years, research on microRNAs (miRNAs) has become a hotspot because of their critical role in regulating posttranscriptional levels of protein-coding genes that may serve as key pathogenic factors in diseases. Several miRNAs were found to participate in the pathogenesis of DN, while others showed renal protective effects. Therefore, targeting miRNAs that are involved in DN may have a good prospect in the treatment of the disease. The aim of this review is to summarize DN-related miRNAs and provide potential targets for diagnostic strategies and therapeutic intervention.
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spelling pubmed-41657342014-09-25 The Role of MicroRNAs in Diabetic Nephropathy Wu, Hao Kong, Lili Zhou, Shanshan Cui, Wenpeng Xu, Feng Luo, Manyu Li, Xiangqi Tan, Yi Miao, Lining J Diabetes Res Review Article Diabetic nephropathy (DN), as one of the chronic complications of diabetes, is the major cause of end-stage renal disease. However, the pathogenesis of this disease is not fully understood. In recent years, research on microRNAs (miRNAs) has become a hotspot because of their critical role in regulating posttranscriptional levels of protein-coding genes that may serve as key pathogenic factors in diseases. Several miRNAs were found to participate in the pathogenesis of DN, while others showed renal protective effects. Therefore, targeting miRNAs that are involved in DN may have a good prospect in the treatment of the disease. The aim of this review is to summarize DN-related miRNAs and provide potential targets for diagnostic strategies and therapeutic intervention. Hindawi Publishing Corporation 2014 2014-09-01 /pmc/articles/PMC4165734/ /pubmed/25258717 http://dx.doi.org/10.1155/2014/920134 Text en Copyright © 2014 Hao Wu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wu, Hao
Kong, Lili
Zhou, Shanshan
Cui, Wenpeng
Xu, Feng
Luo, Manyu
Li, Xiangqi
Tan, Yi
Miao, Lining
The Role of MicroRNAs in Diabetic Nephropathy
title The Role of MicroRNAs in Diabetic Nephropathy
title_full The Role of MicroRNAs in Diabetic Nephropathy
title_fullStr The Role of MicroRNAs in Diabetic Nephropathy
title_full_unstemmed The Role of MicroRNAs in Diabetic Nephropathy
title_short The Role of MicroRNAs in Diabetic Nephropathy
title_sort role of micrornas in diabetic nephropathy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165734/
https://www.ncbi.nlm.nih.gov/pubmed/25258717
http://dx.doi.org/10.1155/2014/920134
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