The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for gXe research

In this commentary I review the recent paper by Iyegbe et al. on "The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for gXe research". I discuss how the paper advances our knowledge of polygenic risk scores for use, amongst others, in...

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Detalles Bibliográficos
Autor principal: Kirkbride, James B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165868/
https://www.ncbi.nlm.nih.gov/pubmed/25193375
http://dx.doi.org/10.1007/s00127-014-0961-6
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author Kirkbride, James B.
author_facet Kirkbride, James B.
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description In this commentary I review the recent paper by Iyegbe et al. on "The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for gXe research". I discuss how the paper advances our knowledge of polygenic risk scores for use, amongst others, in gene-environment interaction studies and the opportunities and challenges such approaches will bring to our understanding of the epidemiology of psychotic disorders, including schizophrenia.
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spelling pubmed-41658682014-09-18 The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for gXe research Kirkbride, James B. Soc Psychiatry Psychiatr Epidemiol Commentary In this commentary I review the recent paper by Iyegbe et al. on "The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for gXe research". I discuss how the paper advances our knowledge of polygenic risk scores for use, amongst others, in gene-environment interaction studies and the opportunities and challenges such approaches will bring to our understanding of the epidemiology of psychotic disorders, including schizophrenia. Springer Berlin Heidelberg 2014-09-06 2014 /pmc/articles/PMC4165868/ /pubmed/25193375 http://dx.doi.org/10.1007/s00127-014-0961-6 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Commentary
Kirkbride, James B.
The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for gXe research
title The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for gXe research
title_full The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for gXe research
title_fullStr The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for gXe research
title_full_unstemmed The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for gXe research
title_short The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for gXe research
title_sort emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for gxe research
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165868/
https://www.ncbi.nlm.nih.gov/pubmed/25193375
http://dx.doi.org/10.1007/s00127-014-0961-6
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