A Cell-Based High-Throughput Screen for Novel Chemical Inducers of Fetal Hemoglobin for Treatment of Hemoglobinopathies

Decades of research have established that the most effective treatment for sickle cell disease (SCD) is increased fetal hemoglobin (HbF). Identification of a drug specific for inducing γ-globin expression in pediatric and adult patients, with minimal off-target effects, continues to be an elusive go...

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Detalles Bibliográficos
Autores principales: Peterson, Kenneth R., Costa, Flávia C., Fedosyuk, Halyna, Neades, Renee Y., Chazelle, Allen M., Zelenchuk, Lesya, Fonteles, Andrea H., Dalal, Parmita, Roy, Anuradha, Chaguturu, Rathnam, Li, Biaoru, Pace, Betty S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165891/
https://www.ncbi.nlm.nih.gov/pubmed/25225870
http://dx.doi.org/10.1371/journal.pone.0107006

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