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Pathogenic influenza B virus in the ferret model establishes lower respiratory tract infection
Influenza B viruses have become increasingly more prominent during influenza seasons. Influenza B infection is typically considered a mild disease and receives less attention than influenza A, but has been causing 20 to 50 % of the total influenza incidence in several regions around the world. Altho...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for General Microbiology
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165929/ https://www.ncbi.nlm.nih.gov/pubmed/24989173 http://dx.doi.org/10.1099/vir.0.064352-0 |
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author | Huang, Stephen S. H. Banner, David Paquette, Stephane G. Leon, Alberto J. Kelvin, Alyson A. Kelvin, David J. |
author_facet | Huang, Stephen S. H. Banner, David Paquette, Stephane G. Leon, Alberto J. Kelvin, Alyson A. Kelvin, David J. |
author_sort | Huang, Stephen S. H. |
collection | PubMed |
description | Influenza B viruses have become increasingly more prominent during influenza seasons. Influenza B infection is typically considered a mild disease and receives less attention than influenza A, but has been causing 20 to 50 % of the total influenza incidence in several regions around the world. Although there is increasing evidence of mid to lower respiratory tract diseases such as bronchitis and pneumonia in influenza B patients, little is known about the pathogenesis of recent influenza B viruses. Here we investigated the clinical and pathological profiles of infection with strains representing the two current co-circulating B lineages (B/Yamagata and B/Victoria) in the ferret model. Specifically, we studied two B/Victoria (B/Brisbane/60/2008 and B/Bolivia/1526/2010) and two B/Yamagata (B/Florida/04/2006 and B/Wisconsin/01/2010) strain infections in ferrets and observed strain-specific but not lineage-specific pathogenicity. We found B/Brisbane/60/2008 caused the most severe clinical illness and B/Brisbane/60/2008 and the B/Yamagata strains instigated pathology in the middle to lower respiratory tract. Importantly, B/Brisbane/60/2008 established efficient lower respiratory tract infection with high viral burden. Our phylogenetic analyses demonstrate profound reassortment among recent influenza B viruses, which indicates the genetic make-up of B/Brisbane/60/2008 differs from the other strains. This may explain the pathogenicity difference post-infection in ferrets. |
format | Online Article Text |
id | pubmed-4165929 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Society for General Microbiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-41659292014-10-07 Pathogenic influenza B virus in the ferret model establishes lower respiratory tract infection Huang, Stephen S. H. Banner, David Paquette, Stephane G. Leon, Alberto J. Kelvin, Alyson A. Kelvin, David J. J Gen Virol Animal Influenza B viruses have become increasingly more prominent during influenza seasons. Influenza B infection is typically considered a mild disease and receives less attention than influenza A, but has been causing 20 to 50 % of the total influenza incidence in several regions around the world. Although there is increasing evidence of mid to lower respiratory tract diseases such as bronchitis and pneumonia in influenza B patients, little is known about the pathogenesis of recent influenza B viruses. Here we investigated the clinical and pathological profiles of infection with strains representing the two current co-circulating B lineages (B/Yamagata and B/Victoria) in the ferret model. Specifically, we studied two B/Victoria (B/Brisbane/60/2008 and B/Bolivia/1526/2010) and two B/Yamagata (B/Florida/04/2006 and B/Wisconsin/01/2010) strain infections in ferrets and observed strain-specific but not lineage-specific pathogenicity. We found B/Brisbane/60/2008 caused the most severe clinical illness and B/Brisbane/60/2008 and the B/Yamagata strains instigated pathology in the middle to lower respiratory tract. Importantly, B/Brisbane/60/2008 established efficient lower respiratory tract infection with high viral burden. Our phylogenetic analyses demonstrate profound reassortment among recent influenza B viruses, which indicates the genetic make-up of B/Brisbane/60/2008 differs from the other strains. This may explain the pathogenicity difference post-infection in ferrets. Society for General Microbiology 2014-10 /pmc/articles/PMC4165929/ /pubmed/24989173 http://dx.doi.org/10.1099/vir.0.064352-0 Text en © 2014 The Authors http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Animal Huang, Stephen S. H. Banner, David Paquette, Stephane G. Leon, Alberto J. Kelvin, Alyson A. Kelvin, David J. Pathogenic influenza B virus in the ferret model establishes lower respiratory tract infection |
title | Pathogenic influenza B virus in the ferret model establishes lower respiratory tract infection |
title_full | Pathogenic influenza B virus in the ferret model establishes lower respiratory tract infection |
title_fullStr | Pathogenic influenza B virus in the ferret model establishes lower respiratory tract infection |
title_full_unstemmed | Pathogenic influenza B virus in the ferret model establishes lower respiratory tract infection |
title_short | Pathogenic influenza B virus in the ferret model establishes lower respiratory tract infection |
title_sort | pathogenic influenza b virus in the ferret model establishes lower respiratory tract infection |
topic | Animal |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165929/ https://www.ncbi.nlm.nih.gov/pubmed/24989173 http://dx.doi.org/10.1099/vir.0.064352-0 |
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