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Pathogenic influenza B virus in the ferret model establishes lower respiratory tract infection

Influenza B viruses have become increasingly more prominent during influenza seasons. Influenza B infection is typically considered a mild disease and receives less attention than influenza A, but has been causing 20 to 50 % of the total influenza incidence in several regions around the world. Altho...

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Autores principales: Huang, Stephen S. H., Banner, David, Paquette, Stephane G., Leon, Alberto J., Kelvin, Alyson A., Kelvin, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for General Microbiology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165929/
https://www.ncbi.nlm.nih.gov/pubmed/24989173
http://dx.doi.org/10.1099/vir.0.064352-0
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author Huang, Stephen S. H.
Banner, David
Paquette, Stephane G.
Leon, Alberto J.
Kelvin, Alyson A.
Kelvin, David J.
author_facet Huang, Stephen S. H.
Banner, David
Paquette, Stephane G.
Leon, Alberto J.
Kelvin, Alyson A.
Kelvin, David J.
author_sort Huang, Stephen S. H.
collection PubMed
description Influenza B viruses have become increasingly more prominent during influenza seasons. Influenza B infection is typically considered a mild disease and receives less attention than influenza A, but has been causing 20 to 50 % of the total influenza incidence in several regions around the world. Although there is increasing evidence of mid to lower respiratory tract diseases such as bronchitis and pneumonia in influenza B patients, little is known about the pathogenesis of recent influenza B viruses. Here we investigated the clinical and pathological profiles of infection with strains representing the two current co-circulating B lineages (B/Yamagata and B/Victoria) in the ferret model. Specifically, we studied two B/Victoria (B/Brisbane/60/2008 and B/Bolivia/1526/2010) and two B/Yamagata (B/Florida/04/2006 and B/Wisconsin/01/2010) strain infections in ferrets and observed strain-specific but not lineage-specific pathogenicity. We found B/Brisbane/60/2008 caused the most severe clinical illness and B/Brisbane/60/2008 and the B/Yamagata strains instigated pathology in the middle to lower respiratory tract. Importantly, B/Brisbane/60/2008 established efficient lower respiratory tract infection with high viral burden. Our phylogenetic analyses demonstrate profound reassortment among recent influenza B viruses, which indicates the genetic make-up of B/Brisbane/60/2008 differs from the other strains. This may explain the pathogenicity difference post-infection in ferrets.
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spelling pubmed-41659292014-10-07 Pathogenic influenza B virus in the ferret model establishes lower respiratory tract infection Huang, Stephen S. H. Banner, David Paquette, Stephane G. Leon, Alberto J. Kelvin, Alyson A. Kelvin, David J. J Gen Virol Animal Influenza B viruses have become increasingly more prominent during influenza seasons. Influenza B infection is typically considered a mild disease and receives less attention than influenza A, but has been causing 20 to 50 % of the total influenza incidence in several regions around the world. Although there is increasing evidence of mid to lower respiratory tract diseases such as bronchitis and pneumonia in influenza B patients, little is known about the pathogenesis of recent influenza B viruses. Here we investigated the clinical and pathological profiles of infection with strains representing the two current co-circulating B lineages (B/Yamagata and B/Victoria) in the ferret model. Specifically, we studied two B/Victoria (B/Brisbane/60/2008 and B/Bolivia/1526/2010) and two B/Yamagata (B/Florida/04/2006 and B/Wisconsin/01/2010) strain infections in ferrets and observed strain-specific but not lineage-specific pathogenicity. We found B/Brisbane/60/2008 caused the most severe clinical illness and B/Brisbane/60/2008 and the B/Yamagata strains instigated pathology in the middle to lower respiratory tract. Importantly, B/Brisbane/60/2008 established efficient lower respiratory tract infection with high viral burden. Our phylogenetic analyses demonstrate profound reassortment among recent influenza B viruses, which indicates the genetic make-up of B/Brisbane/60/2008 differs from the other strains. This may explain the pathogenicity difference post-infection in ferrets. Society for General Microbiology 2014-10 /pmc/articles/PMC4165929/ /pubmed/24989173 http://dx.doi.org/10.1099/vir.0.064352-0 Text en © 2014 The Authors http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Animal
Huang, Stephen S. H.
Banner, David
Paquette, Stephane G.
Leon, Alberto J.
Kelvin, Alyson A.
Kelvin, David J.
Pathogenic influenza B virus in the ferret model establishes lower respiratory tract infection
title Pathogenic influenza B virus in the ferret model establishes lower respiratory tract infection
title_full Pathogenic influenza B virus in the ferret model establishes lower respiratory tract infection
title_fullStr Pathogenic influenza B virus in the ferret model establishes lower respiratory tract infection
title_full_unstemmed Pathogenic influenza B virus in the ferret model establishes lower respiratory tract infection
title_short Pathogenic influenza B virus in the ferret model establishes lower respiratory tract infection
title_sort pathogenic influenza b virus in the ferret model establishes lower respiratory tract infection
topic Animal
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165929/
https://www.ncbi.nlm.nih.gov/pubmed/24989173
http://dx.doi.org/10.1099/vir.0.064352-0
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