The effect of metyrosine/prednisolone combination to oophorectomy-induced osteoporosis

Background: Osteoporosis is a chronic disease characterized by a decrease in bone mineral density (BMD) and corruption of the microarchitectural structure of bone tissue. Objective: It was investigated whether methylprednisolone had a favorable effect on osteoporotic bone tissue in Oophorectomy indu...

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Autores principales: Salman, Suleyman, Kumbasar, Serkan, Hacimuftuoglu, Ahmet, Ozturk, Berna, Seven, Bedri, Polat, Beyzagul, Gundogdu, Cemal, Demirci, Elif, Yildirim, Kadir, Akcay, Fatih, Uslu, Turan, Tuncel Daloglu, Ferrah, Suleyman, Halis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research and Clinical Center for Infertility 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165955/
https://www.ncbi.nlm.nih.gov/pubmed/25246899
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author Salman, Suleyman
Kumbasar, Serkan
Hacimuftuoglu, Ahmet
Ozturk, Berna
Seven, Bedri
Polat, Beyzagul
Gundogdu, Cemal
Demirci, Elif
Yildirim, Kadir
Akcay, Fatih
Uslu, Turan
Tuncel Daloglu, Ferrah
Suleyman, Halis
author_facet Salman, Suleyman
Kumbasar, Serkan
Hacimuftuoglu, Ahmet
Ozturk, Berna
Seven, Bedri
Polat, Beyzagul
Gundogdu, Cemal
Demirci, Elif
Yildirim, Kadir
Akcay, Fatih
Uslu, Turan
Tuncel Daloglu, Ferrah
Suleyman, Halis
author_sort Salman, Suleyman
collection PubMed
description Background: Osteoporosis is a chronic disease characterized by a decrease in bone mineral density (BMD) and corruption of the microarchitectural structure of bone tissue. Objective: It was investigated whether methylprednisolone had a favorable effect on osteoporotic bone tissue in Oophorectomy induced osteoporotic rats whose endogenous adrenaline levels are suppressed with metyrosine. Materials and Methods: Bone Mineral Density, number of osteoblast-osteoclast, bone osteocalcin levels and alkaline phosphatase (ALP) measurements were performed. Obtained results were compared with that of alendronate. Results: Oophorectomy induced osteoporosis was exacerbated by methylprednisolone. Alentronate prevented ovariectomised induced osteoporosis, but it couldn’t prevent methylprednisolone +ovariectomised induced osteoporosis in rats. Conclusion: Combined treatment with methylprednisolon and metyrosine was the best treatment for preventing osteoporosis but metyrosine alone couldn’t prevent osteoporosis in ovariectomised rats.
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spelling pubmed-41659552014-09-22 The effect of metyrosine/prednisolone combination to oophorectomy-induced osteoporosis Salman, Suleyman Kumbasar, Serkan Hacimuftuoglu, Ahmet Ozturk, Berna Seven, Bedri Polat, Beyzagul Gundogdu, Cemal Demirci, Elif Yildirim, Kadir Akcay, Fatih Uslu, Turan Tuncel Daloglu, Ferrah Suleyman, Halis Iran J Reprod Med Original Article Background: Osteoporosis is a chronic disease characterized by a decrease in bone mineral density (BMD) and corruption of the microarchitectural structure of bone tissue. Objective: It was investigated whether methylprednisolone had a favorable effect on osteoporotic bone tissue in Oophorectomy induced osteoporotic rats whose endogenous adrenaline levels are suppressed with metyrosine. Materials and Methods: Bone Mineral Density, number of osteoblast-osteoclast, bone osteocalcin levels and alkaline phosphatase (ALP) measurements were performed. Obtained results were compared with that of alendronate. Results: Oophorectomy induced osteoporosis was exacerbated by methylprednisolone. Alentronate prevented ovariectomised induced osteoporosis, but it couldn’t prevent methylprednisolone +ovariectomised induced osteoporosis in rats. Conclusion: Combined treatment with methylprednisolon and metyrosine was the best treatment for preventing osteoporosis but metyrosine alone couldn’t prevent osteoporosis in ovariectomised rats. Research and Clinical Center for Infertility 2012-07 /pmc/articles/PMC4165955/ /pubmed/25246899 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Salman, Suleyman
Kumbasar, Serkan
Hacimuftuoglu, Ahmet
Ozturk, Berna
Seven, Bedri
Polat, Beyzagul
Gundogdu, Cemal
Demirci, Elif
Yildirim, Kadir
Akcay, Fatih
Uslu, Turan
Tuncel Daloglu, Ferrah
Suleyman, Halis
The effect of metyrosine/prednisolone combination to oophorectomy-induced osteoporosis
title The effect of metyrosine/prednisolone combination to oophorectomy-induced osteoporosis
title_full The effect of metyrosine/prednisolone combination to oophorectomy-induced osteoporosis
title_fullStr The effect of metyrosine/prednisolone combination to oophorectomy-induced osteoporosis
title_full_unstemmed The effect of metyrosine/prednisolone combination to oophorectomy-induced osteoporosis
title_short The effect of metyrosine/prednisolone combination to oophorectomy-induced osteoporosis
title_sort effect of metyrosine/prednisolone combination to oophorectomy-induced osteoporosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165955/
https://www.ncbi.nlm.nih.gov/pubmed/25246899
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