Alteration of Lipid Parameters in Patients With Subclinical Hypothyroidism

BACKGROUND: Overt hypothyroidism is associated with abnormalities of lipid metabolism, but conflicting results regarding the degree of lipid changes in subclinical hypothyroidism (SCH) exist. OBJECTIVES: The aim of this study was to assess differences in lipid profile parameters between subjects with and without SCH in a north Indian population. PATIENTS AND METHODS: Serum lipid parameters of 70 patients with subclinical hypothyroidism and 100 age and sex matched euthyroid controls were evaluated in a cross-sectional study. RESULTS: Mean serum total cholesterol (TC), triglycerides (TG) and very low-density cholesterol (VLDL) were significantly higher in patients with SCH than controls (P < 0.05). Mean TC, TG and low-density cholesterol (LDL) concentrations were higher in patients with serum thyroid stimulating hormone (TSH) greater than 10 mU/L than those with serum TSH equal to or less than 10 mU/L, but this difference was not statistically significant. No association was found between serum high-density cholesterol (HDL-C) concentration and serum TSH level. CONCLUSIONS: High TC, TG and VLDL were observed in our patients with SCH.