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Serum Inflammatory Cytokines and Depression in Coronary Artery Disease

BACKGROUND: Severe depression may be accompanied by immune dysregulation and is also associated with increased risk of coronary artery disease (CAD). OBJECTIVES: We investigated serum levels of 10 cytokines and their relationship with depression in patients with cardiovascular diseases as well as he...

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Autores principales: Tajfard, Mohammad, Latiff, Latiffah A, Rahimi, Hamid Reza, Mouhebati, Mohsen, Esmaeily, Habibollah, Taghipour, Ali, Mahdipour, Elahe, Davari, Hafezeh, Saghiri, Zahra, Hanachi, Parichehr, Ghayour Mobarhan, Majid, Ferns, Gordon A, Azizian, Maryam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166097/
https://www.ncbi.nlm.nih.gov/pubmed/25237578
http://dx.doi.org/10.5812/ircmj.17111
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author Tajfard, Mohammad
Latiff, Latiffah A
Rahimi, Hamid Reza
Mouhebati, Mohsen
Esmaeily, Habibollah
Taghipour, Ali
Mahdipour, Elahe
Davari, Hafezeh
Saghiri, Zahra
Hanachi, Parichehr
Ghayour Mobarhan, Majid
Ferns, Gordon A
Azizian, Maryam
author_facet Tajfard, Mohammad
Latiff, Latiffah A
Rahimi, Hamid Reza
Mouhebati, Mohsen
Esmaeily, Habibollah
Taghipour, Ali
Mahdipour, Elahe
Davari, Hafezeh
Saghiri, Zahra
Hanachi, Parichehr
Ghayour Mobarhan, Majid
Ferns, Gordon A
Azizian, Maryam
author_sort Tajfard, Mohammad
collection PubMed
description BACKGROUND: Severe depression may be accompanied by immune dysregulation and is also associated with increased risk of coronary artery disease (CAD). OBJECTIVES: We investigated serum levels of 10 cytokines and their relationship with depression in patients with cardiovascular diseases as well as healthy subjects in northeast of Iran. PATIENTS AND METHODS: The study was carried out on 462 subjects (120 healthy subjects and 342 candidates undergoing angiography). The healthy subjects were referred for routine annual checkups or pre-employment examinations; they did not have clinically evident CAD. A questionnaire was used to obtain demographic data and the Beck depression inventory (BDI) was applied to assess depression. The Evidence Investigator(®) platform was used for cytokines assays for IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-α, MCP-1 and IFN-γ, using sandwich chemiluminescent method. The statistical analysis was performed using SPSS version 11.5. RESULTS: The mean age was 53.3 ± 11.5, 54.8 ± 11.3, and 59.5 ± 11.3 in healthy, angiography (-), and angiography (+) subjects, respectively (P < 0.05). There were significant differences in serum levels of IL-4, IL-6, IL-10, and MCP-1 cytokines, comparing subjects with CAD and healthy persons (P < 0.05). When all subjects were divided to with and without depression regardless of their cardiovascular status, there was a significant difference in serum levels of IL-8 and IL-6 between the groups (P < 0.05). When the subgroup with features of CAD was selected and divided to those with and without depression, there was also a significant difference in serum levels of IL-8 and TNF-α (P < 0.05). CONCLUSIONS: The positive interaction between depression and CAD was probably mediated by inflammatory mechanisms.
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spelling pubmed-41660972014-09-18 Serum Inflammatory Cytokines and Depression in Coronary Artery Disease Tajfard, Mohammad Latiff, Latiffah A Rahimi, Hamid Reza Mouhebati, Mohsen Esmaeily, Habibollah Taghipour, Ali Mahdipour, Elahe Davari, Hafezeh Saghiri, Zahra Hanachi, Parichehr Ghayour Mobarhan, Majid Ferns, Gordon A Azizian, Maryam Iran Red Crescent Med J Research Article BACKGROUND: Severe depression may be accompanied by immune dysregulation and is also associated with increased risk of coronary artery disease (CAD). OBJECTIVES: We investigated serum levels of 10 cytokines and their relationship with depression in patients with cardiovascular diseases as well as healthy subjects in northeast of Iran. PATIENTS AND METHODS: The study was carried out on 462 subjects (120 healthy subjects and 342 candidates undergoing angiography). The healthy subjects were referred for routine annual checkups or pre-employment examinations; they did not have clinically evident CAD. A questionnaire was used to obtain demographic data and the Beck depression inventory (BDI) was applied to assess depression. The Evidence Investigator(®) platform was used for cytokines assays for IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-α, MCP-1 and IFN-γ, using sandwich chemiluminescent method. The statistical analysis was performed using SPSS version 11.5. RESULTS: The mean age was 53.3 ± 11.5, 54.8 ± 11.3, and 59.5 ± 11.3 in healthy, angiography (-), and angiography (+) subjects, respectively (P < 0.05). There were significant differences in serum levels of IL-4, IL-6, IL-10, and MCP-1 cytokines, comparing subjects with CAD and healthy persons (P < 0.05). When all subjects were divided to with and without depression regardless of their cardiovascular status, there was a significant difference in serum levels of IL-8 and IL-6 between the groups (P < 0.05). When the subgroup with features of CAD was selected and divided to those with and without depression, there was also a significant difference in serum levels of IL-8 and TNF-α (P < 0.05). CONCLUSIONS: The positive interaction between depression and CAD was probably mediated by inflammatory mechanisms. Kowsar 2014-07-05 2014-07 /pmc/articles/PMC4166097/ /pubmed/25237578 http://dx.doi.org/10.5812/ircmj.17111 Text en Copyright © 2014, Iranian Red Crescent Medical Journal; Published by Kowsar Corp. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Tajfard, Mohammad
Latiff, Latiffah A
Rahimi, Hamid Reza
Mouhebati, Mohsen
Esmaeily, Habibollah
Taghipour, Ali
Mahdipour, Elahe
Davari, Hafezeh
Saghiri, Zahra
Hanachi, Parichehr
Ghayour Mobarhan, Majid
Ferns, Gordon A
Azizian, Maryam
Serum Inflammatory Cytokines and Depression in Coronary Artery Disease
title Serum Inflammatory Cytokines and Depression in Coronary Artery Disease
title_full Serum Inflammatory Cytokines and Depression in Coronary Artery Disease
title_fullStr Serum Inflammatory Cytokines and Depression in Coronary Artery Disease
title_full_unstemmed Serum Inflammatory Cytokines and Depression in Coronary Artery Disease
title_short Serum Inflammatory Cytokines and Depression in Coronary Artery Disease
title_sort serum inflammatory cytokines and depression in coronary artery disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166097/
https://www.ncbi.nlm.nih.gov/pubmed/25237578
http://dx.doi.org/10.5812/ircmj.17111
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