Direct stimulation of bone mass by increased GH signalling in the osteoblasts of Socs2(−/−) mice

The suppressor of cytokine signalling (Socs2 (−/−))-knockout mouse is characterised by an overgrowth phenotype due to enhanced GH signalling. The objective of this study was to define the Socs2 (−/−) bone phenotype and determine whether GH promotes bone mass via IGF1-dependent mechanisms. Despite no...

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Detalles Bibliográficos
Autores principales: Dobie, R, MacRae, V E, Huesa, C, van't Hof, R, Ahmed, S F, Farquharson, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166176/
https://www.ncbi.nlm.nih.gov/pubmed/25074853
http://dx.doi.org/10.1530/JOE-14-0292

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166176/
https://www.ncbi.nlm.nih.gov/pubmed/25074853
http://dx.doi.org/10.1530/JOE-14-0292

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