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Prognostic values of highly sensitive cardiac troponin T and B-type natriuretic peptide for clinical features in hypertrophic obstructive cardiomyopathy: a cross-sectional study
OBJECTIVES: Although B-type natriuretic peptide (BNP) and highly sensitive cardiac troponin T (cTnT) are useful for the evaluation of clinical features in various cardiovascular diseases, there are comparatively few data regarding the utility of these parameters in patients with hypertrophic obstruc...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166252/ https://www.ncbi.nlm.nih.gov/pubmed/25231494 http://dx.doi.org/10.1136/bmjopen-2014-005968 |
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author | Nakamura, Shunichi Takano, Hitoshi Matsuda, Junya Chinen, Daigo Kitamura, Mitsunobu Murai, Koji Asai, Kuniya Yasutake, Masahiro Takayama, Morimasa Shimizu, Wataru |
author_facet | Nakamura, Shunichi Takano, Hitoshi Matsuda, Junya Chinen, Daigo Kitamura, Mitsunobu Murai, Koji Asai, Kuniya Yasutake, Masahiro Takayama, Morimasa Shimizu, Wataru |
author_sort | Nakamura, Shunichi |
collection | PubMed |
description | OBJECTIVES: Although B-type natriuretic peptide (BNP) and highly sensitive cardiac troponin T (cTnT) are useful for the evaluation of clinical features in various cardiovascular diseases, there are comparatively few data regarding the utility of these parameters in patients with hypertrophic obstructive cardiomyopathy (HOCM). The goal of this study was to assess the association between BNP, cTnT and clinical parameters in patients with HOCM. DESIGN: Cross-sectional survey SETTINGS: The relationship between BNP, cTnT and clinical end points and echocardiographic data was investigated. PARTICIPANTS: This study included 102 consecutive outpatients with HOCM who were clinically stable. RESULTS: BNP was significantly associated with both maximum left ventricular (LV) wall thickness (r=0.28; p=0.003), and septal peak early transmitral filling velocity/peak early diastolic mitral annulus velocity (r=0.51; p=0.0001). No statistically significant associations were seen between cTnT and any echocardiographic parameters, but the presence of atrial fibrillation (AF) was associated with a high level of cTnT (p=0.01). CONCLUSIONS: BNP is useful for monitoring clinical parameters and as a reflection of both LV systolic/diastolic function and increased LV pressure in patients with HOCM. A high level of serum cTnT is associated with the presence of AF. |
format | Online Article Text |
id | pubmed-4166252 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-41662522014-09-22 Prognostic values of highly sensitive cardiac troponin T and B-type natriuretic peptide for clinical features in hypertrophic obstructive cardiomyopathy: a cross-sectional study Nakamura, Shunichi Takano, Hitoshi Matsuda, Junya Chinen, Daigo Kitamura, Mitsunobu Murai, Koji Asai, Kuniya Yasutake, Masahiro Takayama, Morimasa Shimizu, Wataru BMJ Open Cardiovascular Medicine OBJECTIVES: Although B-type natriuretic peptide (BNP) and highly sensitive cardiac troponin T (cTnT) are useful for the evaluation of clinical features in various cardiovascular diseases, there are comparatively few data regarding the utility of these parameters in patients with hypertrophic obstructive cardiomyopathy (HOCM). The goal of this study was to assess the association between BNP, cTnT and clinical parameters in patients with HOCM. DESIGN: Cross-sectional survey SETTINGS: The relationship between BNP, cTnT and clinical end points and echocardiographic data was investigated. PARTICIPANTS: This study included 102 consecutive outpatients with HOCM who were clinically stable. RESULTS: BNP was significantly associated with both maximum left ventricular (LV) wall thickness (r=0.28; p=0.003), and septal peak early transmitral filling velocity/peak early diastolic mitral annulus velocity (r=0.51; p=0.0001). No statistically significant associations were seen between cTnT and any echocardiographic parameters, but the presence of atrial fibrillation (AF) was associated with a high level of cTnT (p=0.01). CONCLUSIONS: BNP is useful for monitoring clinical parameters and as a reflection of both LV systolic/diastolic function and increased LV pressure in patients with HOCM. A high level of serum cTnT is associated with the presence of AF. BMJ Publishing Group 2014-09-17 /pmc/articles/PMC4166252/ /pubmed/25231494 http://dx.doi.org/10.1136/bmjopen-2014-005968 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Cardiovascular Medicine Nakamura, Shunichi Takano, Hitoshi Matsuda, Junya Chinen, Daigo Kitamura, Mitsunobu Murai, Koji Asai, Kuniya Yasutake, Masahiro Takayama, Morimasa Shimizu, Wataru Prognostic values of highly sensitive cardiac troponin T and B-type natriuretic peptide for clinical features in hypertrophic obstructive cardiomyopathy: a cross-sectional study |
title | Prognostic values of highly sensitive cardiac troponin T and B-type natriuretic peptide for clinical features in hypertrophic obstructive cardiomyopathy: a cross-sectional study |
title_full | Prognostic values of highly sensitive cardiac troponin T and B-type natriuretic peptide for clinical features in hypertrophic obstructive cardiomyopathy: a cross-sectional study |
title_fullStr | Prognostic values of highly sensitive cardiac troponin T and B-type natriuretic peptide for clinical features in hypertrophic obstructive cardiomyopathy: a cross-sectional study |
title_full_unstemmed | Prognostic values of highly sensitive cardiac troponin T and B-type natriuretic peptide for clinical features in hypertrophic obstructive cardiomyopathy: a cross-sectional study |
title_short | Prognostic values of highly sensitive cardiac troponin T and B-type natriuretic peptide for clinical features in hypertrophic obstructive cardiomyopathy: a cross-sectional study |
title_sort | prognostic values of highly sensitive cardiac troponin t and b-type natriuretic peptide for clinical features in hypertrophic obstructive cardiomyopathy: a cross-sectional study |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166252/ https://www.ncbi.nlm.nih.gov/pubmed/25231494 http://dx.doi.org/10.1136/bmjopen-2014-005968 |
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