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Endothelial keratoplasty with infant donor tissue

Here we report a case of endothelial keratoplasty with infant donor tissue obtained after brain death. A 52-year-old man with endothelial dysfunction of unknown cause in the right eye underwent non-Descemet stripping automated endothelial keratoplasty (nDSAEK) with tissue from an infant donor (2 yea...

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Autores principales: Kobayashi, Akira, Yokogawa, Hideaki, Yamazaki, Natsuko, Masaki, Toshinori, Sugiyama, Kazuhisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166343/
https://www.ncbi.nlm.nih.gov/pubmed/25246761
http://dx.doi.org/10.2147/OPTH.S68618
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author Kobayashi, Akira
Yokogawa, Hideaki
Yamazaki, Natsuko
Masaki, Toshinori
Sugiyama, Kazuhisa
author_facet Kobayashi, Akira
Yokogawa, Hideaki
Yamazaki, Natsuko
Masaki, Toshinori
Sugiyama, Kazuhisa
author_sort Kobayashi, Akira
collection PubMed
description Here we report a case of endothelial keratoplasty with infant donor tissue obtained after brain death. A 52-year-old man with endothelial dysfunction of unknown cause in the right eye underwent non-Descemet stripping automated endothelial keratoplasty (nDSAEK) with tissue from an infant donor (2 years). Intraoperative and postoperative complications were recorded. Best corrected visual acuity and donor central endothelial cell density were recorded preoperatively and postoperatively. Infant donor tissue preparation with a microkeratome set at 300 μm was successful; the donor tissue was extremely elastic and soft compared with adult tissue. The central endothelial cell density of the infant donor tissue was as high as 4,291 cells/mm(2). No complications were observed during donor tissue (8.0 mm in diameter) insertion with the double-glide technique (Busin glide with intraocular lens sheet glide) or any of the other procedures. Best corrected visual acuity improved from 1.7 logMAR (logarithm of the minimum angle of resolution; 0.02 decimal visual acuity) preoperatively to 0.2 logMAR (0.6) after 6 months and 0.1 logMAR (0.8) after 1 year. The central endothelial cell density after 6 months was 4,098 cells/mm(2) (representing a 4.5% cell loss from preoperative donor cell measurements), and the central endothelial cell density after 1 year was 4,032 cells/mm(2) (6.0% decrease). Infant donor tissue may be preferably used for DSAEK/nDASEK, since it may not be suitable for penetrating keratoplasty or Descemet membrane endothelial keratoplasty.
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spelling pubmed-41663432014-09-22 Endothelial keratoplasty with infant donor tissue Kobayashi, Akira Yokogawa, Hideaki Yamazaki, Natsuko Masaki, Toshinori Sugiyama, Kazuhisa Clin Ophthalmol Case Report Here we report a case of endothelial keratoplasty with infant donor tissue obtained after brain death. A 52-year-old man with endothelial dysfunction of unknown cause in the right eye underwent non-Descemet stripping automated endothelial keratoplasty (nDSAEK) with tissue from an infant donor (2 years). Intraoperative and postoperative complications were recorded. Best corrected visual acuity and donor central endothelial cell density were recorded preoperatively and postoperatively. Infant donor tissue preparation with a microkeratome set at 300 μm was successful; the donor tissue was extremely elastic and soft compared with adult tissue. The central endothelial cell density of the infant donor tissue was as high as 4,291 cells/mm(2). No complications were observed during donor tissue (8.0 mm in diameter) insertion with the double-glide technique (Busin glide with intraocular lens sheet glide) or any of the other procedures. Best corrected visual acuity improved from 1.7 logMAR (logarithm of the minimum angle of resolution; 0.02 decimal visual acuity) preoperatively to 0.2 logMAR (0.6) after 6 months and 0.1 logMAR (0.8) after 1 year. The central endothelial cell density after 6 months was 4,098 cells/mm(2) (representing a 4.5% cell loss from preoperative donor cell measurements), and the central endothelial cell density after 1 year was 4,032 cells/mm(2) (6.0% decrease). Infant donor tissue may be preferably used for DSAEK/nDASEK, since it may not be suitable for penetrating keratoplasty or Descemet membrane endothelial keratoplasty. Dove Medical Press 2014-09-11 /pmc/articles/PMC4166343/ /pubmed/25246761 http://dx.doi.org/10.2147/OPTH.S68618 Text en © 2014 Kobayashi et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Case Report
Kobayashi, Akira
Yokogawa, Hideaki
Yamazaki, Natsuko
Masaki, Toshinori
Sugiyama, Kazuhisa
Endothelial keratoplasty with infant donor tissue
title Endothelial keratoplasty with infant donor tissue
title_full Endothelial keratoplasty with infant donor tissue
title_fullStr Endothelial keratoplasty with infant donor tissue
title_full_unstemmed Endothelial keratoplasty with infant donor tissue
title_short Endothelial keratoplasty with infant donor tissue
title_sort endothelial keratoplasty with infant donor tissue
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166343/
https://www.ncbi.nlm.nih.gov/pubmed/25246761
http://dx.doi.org/10.2147/OPTH.S68618
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