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Spiny neurons of amygdala, striatum, and cortex use dendritic plateau potentials to detect network UP states
Spiny neurons of amygdala, striatum, and cerebral cortex share four interesting features: (1) they are the most abundant cell type within their respective brain area, (2) covered by thousands of thorny protrusions (dendritic spines), (3) possess high levels of dendritic NMDA conductances, and (4) ex...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166350/ https://www.ncbi.nlm.nih.gov/pubmed/25278841 http://dx.doi.org/10.3389/fncel.2014.00292 |
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author | Oikonomou, Katerina D. Singh, Mandakini B. Sterjanaj, Enas V. Antic, Srdjan D. |
author_facet | Oikonomou, Katerina D. Singh, Mandakini B. Sterjanaj, Enas V. Antic, Srdjan D. |
author_sort | Oikonomou, Katerina D. |
collection | PubMed |
description | Spiny neurons of amygdala, striatum, and cerebral cortex share four interesting features: (1) they are the most abundant cell type within their respective brain area, (2) covered by thousands of thorny protrusions (dendritic spines), (3) possess high levels of dendritic NMDA conductances, and (4) experience sustained somatic depolarizations in vivo and in vitro (UP states). In all spiny neurons of the forebrain, adequate glutamatergic inputs generate dendritic plateau potentials (“dendritic UP states”) characterized by (i) fast rise, (ii) plateau phase lasting several hundred milliseconds, and (iii) abrupt decline at the end of the plateau phase. The dendritic plateau potential propagates toward the cell body decrementally to induce a long-lasting (longer than 100 ms, most often 200–800 ms) steady depolarization (∼20 mV amplitude), which resembles a neuronal UP state. Based on voltage-sensitive dye imaging, the plateau depolarization in the soma is precisely time-locked to the regenerative plateau potential taking place in the dendrite. The somatic plateau rises after the onset of the dendritic voltage transient and collapses with the breakdown of the dendritic plateau depolarization. We hypothesize that neuronal UP states in vivo reflect the occurrence of dendritic plateau potentials (dendritic UP states). We propose that the somatic voltage waveform during a neuronal UP state is determined by dendritic plateau potentials. A mammalian spiny neuron uses dendritic plateau potentials to detect and transform coherent network activity into a ubiquitous neuronal UP state. The biophysical properties of dendritic plateau potentials allow neurons to quickly attune to the ongoing network activity, as well as secure the stable amplitudes of successive UP states. |
format | Online Article Text |
id | pubmed-4166350 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-41663502014-10-02 Spiny neurons of amygdala, striatum, and cortex use dendritic plateau potentials to detect network UP states Oikonomou, Katerina D. Singh, Mandakini B. Sterjanaj, Enas V. Antic, Srdjan D. Front Cell Neurosci Neuroscience Spiny neurons of amygdala, striatum, and cerebral cortex share four interesting features: (1) they are the most abundant cell type within their respective brain area, (2) covered by thousands of thorny protrusions (dendritic spines), (3) possess high levels of dendritic NMDA conductances, and (4) experience sustained somatic depolarizations in vivo and in vitro (UP states). In all spiny neurons of the forebrain, adequate glutamatergic inputs generate dendritic plateau potentials (“dendritic UP states”) characterized by (i) fast rise, (ii) plateau phase lasting several hundred milliseconds, and (iii) abrupt decline at the end of the plateau phase. The dendritic plateau potential propagates toward the cell body decrementally to induce a long-lasting (longer than 100 ms, most often 200–800 ms) steady depolarization (∼20 mV amplitude), which resembles a neuronal UP state. Based on voltage-sensitive dye imaging, the plateau depolarization in the soma is precisely time-locked to the regenerative plateau potential taking place in the dendrite. The somatic plateau rises after the onset of the dendritic voltage transient and collapses with the breakdown of the dendritic plateau depolarization. We hypothesize that neuronal UP states in vivo reflect the occurrence of dendritic plateau potentials (dendritic UP states). We propose that the somatic voltage waveform during a neuronal UP state is determined by dendritic plateau potentials. A mammalian spiny neuron uses dendritic plateau potentials to detect and transform coherent network activity into a ubiquitous neuronal UP state. The biophysical properties of dendritic plateau potentials allow neurons to quickly attune to the ongoing network activity, as well as secure the stable amplitudes of successive UP states. Frontiers Media S.A. 2014-09-17 /pmc/articles/PMC4166350/ /pubmed/25278841 http://dx.doi.org/10.3389/fncel.2014.00292 Text en Copyright © 2014 Oikonomou, Singh, Sterjanaj and Antic. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Oikonomou, Katerina D. Singh, Mandakini B. Sterjanaj, Enas V. Antic, Srdjan D. Spiny neurons of amygdala, striatum, and cortex use dendritic plateau potentials to detect network UP states |
title | Spiny neurons of amygdala, striatum, and cortex use dendritic plateau potentials to detect network UP states |
title_full | Spiny neurons of amygdala, striatum, and cortex use dendritic plateau potentials to detect network UP states |
title_fullStr | Spiny neurons of amygdala, striatum, and cortex use dendritic plateau potentials to detect network UP states |
title_full_unstemmed | Spiny neurons of amygdala, striatum, and cortex use dendritic plateau potentials to detect network UP states |
title_short | Spiny neurons of amygdala, striatum, and cortex use dendritic plateau potentials to detect network UP states |
title_sort | spiny neurons of amygdala, striatum, and cortex use dendritic plateau potentials to detect network up states |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166350/ https://www.ncbi.nlm.nih.gov/pubmed/25278841 http://dx.doi.org/10.3389/fncel.2014.00292 |
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