Development of synchronous VHL syndrome tumors reveals contingencies and constraints to tumor evolution

BACKGROUND: Genomic analysis of multi-focal renal cell carcinomas from an individual with a germline VHL mutation offers a unique opportunity to study tumor evolution. RESULTS: We perform whole exome sequencing on four clear cell renal cell carcinomas removed from both kidneys of a patient with a ge...

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Detalles Bibliográficos
Autores principales: Fisher, Rosalie, Horswell, Stuart, Rowan, Andrew, Salm, Maximilian P, de Bruin, Elza C, Gulati, Sakshi, McGranahan, Nicholas, Stares, Mark, Gerlinger, Marco, Varela, Ignacio, Crockford, Andrew, Favero, Francesco, Quidville, Virginie, André, Fabrice, Navas, Carolina, Grönroos, Eva, Nicol, David, Hazell, Steve, Hrouda, David, O’Brien, Tim, Matthews, Nik, Phillimore, Ben, Begum, Sharmin, Rabinowitz, Adam, Biggs, Jennifer, Bates, Paul A, McDonald, Neil Q, Stamp, Gordon, Spencer-Dene, Bradley, Hsieh, James J, Xu, Jianing, Pickering, Lisa, Gore, Martin, Larkin, James, Swanton, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166471/
https://www.ncbi.nlm.nih.gov/pubmed/25159823
http://dx.doi.org/10.1186/s13059-014-0433-z

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