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Rapid establishment of a HEK 293 cell line expressing FVIII-BDD using AAV site-specific integration plasmids
BACKGROUND: Stable human cell lines have gradually become the preferred system for large scale production of recombinant proteins for clinical applications because of their capacity of proper protein post-translational modification and low immunogenicity. However, human cell line development technol...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166473/ https://www.ncbi.nlm.nih.gov/pubmed/25204455 http://dx.doi.org/10.1186/1756-0500-7-626 |