Cooccurrence of Darier's Disease and Epilepsy: A Pediatric Case Report and Review of the Literature

Darier's disease is a skin disorder characterized by multiple eruptions of hyperkeratosis or crusted papules at seborrheic areas with histologic acantholysis and dyskeratosis. It is caused by mutations in a single gene, being ATP2A2 and that is expressed in the skin and brain. The cooccurrence...

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Detalles Bibliográficos
Autores principales: Celik, Tamer, Celik, Umit, Donmezer, Cigdem, Komur, Mustafa, Tolunay, Orkun, Demirtürk, Pelin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166657/
https://www.ncbi.nlm.nih.gov/pubmed/25258690
http://dx.doi.org/10.1155/2014/831398
Descripción
Sumario:Darier's disease is a skin disorder characterized by multiple eruptions of hyperkeratosis or crusted papules at seborrheic areas with histologic acantholysis and dyskeratosis. It is caused by mutations in a single gene, being ATP2A2 and that is expressed in the skin and brain. The cooccurrence of various neurologic and psychiatric diseases with Darier's disease has been reported frequently in literature. They include mood disorders, epilepsy, encephalopathy, and schizophrenia. In this study, we report a pediatric case with the cooccurrence of Darier's disease and epilepsy. We also revised current English literature on this topic.

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