Pubertal Onset in Girls is Strongly Influenced by Genetic Variation Affecting FSH Action

Age at pubertal onset varies substantially in healthy girls. Although genetic factors are responsible for more than half of the phenotypic variation, only a small part has been attributed to specific genetic polymorphisms identified so far. Follicle-stimulating hormone (FSH) stimulates ovarian folli...

Descripción completa

Detalles Bibliográficos
Autores principales: Hagen, Casper P., Sørensen, Kaspar, Aksglaede, Lise, Mouritsen, Annette, Mieritz, Mikkel G., Tinggaard, Jeanette, Wohlfart-Veje, Christine, Petersen, Jørgen Holm, Main, Katharina M., Meyts, Ewa Rajpert-De, Almstrup, Kristian, Juul, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166707/
https://www.ncbi.nlm.nih.gov/pubmed/25231187
http://dx.doi.org/10.1038/srep06412
_version_ 1782335298810675200
author Hagen, Casper P.
Sørensen, Kaspar
Aksglaede, Lise
Mouritsen, Annette
Mieritz, Mikkel G.
Tinggaard, Jeanette
Wohlfart-Veje, Christine
Petersen, Jørgen Holm
Main, Katharina M.
Meyts, Ewa Rajpert-De
Almstrup, Kristian
Juul, Anders
author_facet Hagen, Casper P.
Sørensen, Kaspar
Aksglaede, Lise
Mouritsen, Annette
Mieritz, Mikkel G.
Tinggaard, Jeanette
Wohlfart-Veje, Christine
Petersen, Jørgen Holm
Main, Katharina M.
Meyts, Ewa Rajpert-De
Almstrup, Kristian
Juul, Anders
author_sort Hagen, Casper P.
collection PubMed
description Age at pubertal onset varies substantially in healthy girls. Although genetic factors are responsible for more than half of the phenotypic variation, only a small part has been attributed to specific genetic polymorphisms identified so far. Follicle-stimulating hormone (FSH) stimulates ovarian follicle maturation and estradiol synthesis which is responsible for breast development. We assessed the effect of three polymorphisms influencing FSH action on age at breast deveopment in a population-based cohort of 964 healthy girls. Girls homozygous for FSHR -29AA (reduced FSH receptor expression) entered puberty 7.4 (2.5–12.4) months later than carriers of the common variants FSHR -29GG+GA, p = 0.003. To our knowledge, this is the strongest genetic effect on age at pubertal onset in girls published to date.
format Online
Article
Text
id pubmed-4166707
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-41667072014-09-24 Pubertal Onset in Girls is Strongly Influenced by Genetic Variation Affecting FSH Action Hagen, Casper P. Sørensen, Kaspar Aksglaede, Lise Mouritsen, Annette Mieritz, Mikkel G. Tinggaard, Jeanette Wohlfart-Veje, Christine Petersen, Jørgen Holm Main, Katharina M. Meyts, Ewa Rajpert-De Almstrup, Kristian Juul, Anders Sci Rep Article Age at pubertal onset varies substantially in healthy girls. Although genetic factors are responsible for more than half of the phenotypic variation, only a small part has been attributed to specific genetic polymorphisms identified so far. Follicle-stimulating hormone (FSH) stimulates ovarian follicle maturation and estradiol synthesis which is responsible for breast development. We assessed the effect of three polymorphisms influencing FSH action on age at breast deveopment in a population-based cohort of 964 healthy girls. Girls homozygous for FSHR -29AA (reduced FSH receptor expression) entered puberty 7.4 (2.5–12.4) months later than carriers of the common variants FSHR -29GG+GA, p = 0.003. To our knowledge, this is the strongest genetic effect on age at pubertal onset in girls published to date. Nature Publishing Group 2014-09-18 /pmc/articles/PMC4166707/ /pubmed/25231187 http://dx.doi.org/10.1038/srep06412 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Article
Hagen, Casper P.
Sørensen, Kaspar
Aksglaede, Lise
Mouritsen, Annette
Mieritz, Mikkel G.
Tinggaard, Jeanette
Wohlfart-Veje, Christine
Petersen, Jørgen Holm
Main, Katharina M.
Meyts, Ewa Rajpert-De
Almstrup, Kristian
Juul, Anders
Pubertal Onset in Girls is Strongly Influenced by Genetic Variation Affecting FSH Action
title Pubertal Onset in Girls is Strongly Influenced by Genetic Variation Affecting FSH Action
title_full Pubertal Onset in Girls is Strongly Influenced by Genetic Variation Affecting FSH Action
title_fullStr Pubertal Onset in Girls is Strongly Influenced by Genetic Variation Affecting FSH Action
title_full_unstemmed Pubertal Onset in Girls is Strongly Influenced by Genetic Variation Affecting FSH Action
title_short Pubertal Onset in Girls is Strongly Influenced by Genetic Variation Affecting FSH Action
title_sort pubertal onset in girls is strongly influenced by genetic variation affecting fsh action
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166707/
https://www.ncbi.nlm.nih.gov/pubmed/25231187
http://dx.doi.org/10.1038/srep06412
work_keys_str_mv AT hagencasperp pubertalonsetingirlsisstronglyinfluencedbygeneticvariationaffectingfshaction
AT sørensenkaspar pubertalonsetingirlsisstronglyinfluencedbygeneticvariationaffectingfshaction
AT aksglaedelise pubertalonsetingirlsisstronglyinfluencedbygeneticvariationaffectingfshaction
AT mouritsenannette pubertalonsetingirlsisstronglyinfluencedbygeneticvariationaffectingfshaction
AT mieritzmikkelg pubertalonsetingirlsisstronglyinfluencedbygeneticvariationaffectingfshaction
AT tinggaardjeanette pubertalonsetingirlsisstronglyinfluencedbygeneticvariationaffectingfshaction
AT wohlfartvejechristine pubertalonsetingirlsisstronglyinfluencedbygeneticvariationaffectingfshaction
AT petersenjørgenholm pubertalonsetingirlsisstronglyinfluencedbygeneticvariationaffectingfshaction
AT mainkatharinam pubertalonsetingirlsisstronglyinfluencedbygeneticvariationaffectingfshaction
AT meytsewarajpertde pubertalonsetingirlsisstronglyinfluencedbygeneticvariationaffectingfshaction
AT almstrupkristian pubertalonsetingirlsisstronglyinfluencedbygeneticvariationaffectingfshaction
AT juulanders pubertalonsetingirlsisstronglyinfluencedbygeneticvariationaffectingfshaction

Ejemplares similares