Expression of p27Kip1 and E-cadherin in Head and Neck Squamous Cell Carcinoma of Indonesian Patients

Cancer cells exhibit characteristic damage of DNA and its expression. The expression of the tumor suppressors E-cadherin and p27(Kip1) has been tested on 57 head and neck squamous cell carcinomas (HNSCC) of Indonesian subjects. HNSCC tumor samples including both primary and (unrelated) nodal cases w...

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Autores principales: Auerkari, E.I, Joewono, V, Handjari, D.R, Sarwono, A.T, Suhartono, A.W, Eto, K, Ikeda, M.A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166792/
https://www.ncbi.nlm.nih.gov/pubmed/25246990
http://dx.doi.org/10.2174/1874210601408010136
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author Auerkari, E.I
Joewono, V
Handjari, D.R
Sarwono, A.T
Suhartono, A.W
Eto, K
Ikeda, M.A
author_facet Auerkari, E.I
Joewono, V
Handjari, D.R
Sarwono, A.T
Suhartono, A.W
Eto, K
Ikeda, M.A
author_sort Auerkari, E.I
collection PubMed
description Cancer cells exhibit characteristic damage of DNA and its expression. The expression of the tumor suppressors E-cadherin and p27(Kip1) has been tested on 57 head and neck squamous cell carcinomas (HNSCC) of Indonesian subjects. HNSCC tumor samples including both primary and (unrelated) nodal cases were obtained from the archives of Indonesian hospitals, in accordance with acknowledged ethical requirements. Only modest correlation was found between reduced expression of E-cadherin or p27(Kip1) with increased malignancy of primary and nodal growth. The observed strong correlation regardless of malignancy between the expressed levels of E-cadherin and p27(Kip1) suggests that also in combination these would not help to better predict the outcome of HNSCC.
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spelling pubmed-41667922014-09-22 Expression of p27Kip1 and E-cadherin in Head and Neck Squamous Cell Carcinoma of Indonesian Patients Auerkari, E.I Joewono, V Handjari, D.R Sarwono, A.T Suhartono, A.W Eto, K Ikeda, M.A Open Dent J Article Cancer cells exhibit characteristic damage of DNA and its expression. The expression of the tumor suppressors E-cadherin and p27(Kip1) has been tested on 57 head and neck squamous cell carcinomas (HNSCC) of Indonesian subjects. HNSCC tumor samples including both primary and (unrelated) nodal cases were obtained from the archives of Indonesian hospitals, in accordance with acknowledged ethical requirements. Only modest correlation was found between reduced expression of E-cadherin or p27(Kip1) with increased malignancy of primary and nodal growth. The observed strong correlation regardless of malignancy between the expressed levels of E-cadherin and p27(Kip1) suggests that also in combination these would not help to better predict the outcome of HNSCC. Bentham Open 2014-09-08 /pmc/articles/PMC4166792/ /pubmed/25246990 http://dx.doi.org/10.2174/1874210601408010136 Text en © Auerkari et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Auerkari, E.I
Joewono, V
Handjari, D.R
Sarwono, A.T
Suhartono, A.W
Eto, K
Ikeda, M.A
Expression of p27Kip1 and E-cadherin in Head and Neck Squamous Cell Carcinoma of Indonesian Patients
title Expression of p27Kip1 and E-cadherin in Head and Neck Squamous Cell Carcinoma of Indonesian Patients
title_full Expression of p27Kip1 and E-cadherin in Head and Neck Squamous Cell Carcinoma of Indonesian Patients
title_fullStr Expression of p27Kip1 and E-cadherin in Head and Neck Squamous Cell Carcinoma of Indonesian Patients
title_full_unstemmed Expression of p27Kip1 and E-cadherin in Head and Neck Squamous Cell Carcinoma of Indonesian Patients
title_short Expression of p27Kip1 and E-cadherin in Head and Neck Squamous Cell Carcinoma of Indonesian Patients
title_sort expression of p27kip1 and e-cadherin in head and neck squamous cell carcinoma of indonesian patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166792/
https://www.ncbi.nlm.nih.gov/pubmed/25246990
http://dx.doi.org/10.2174/1874210601408010136
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