Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle

Pericytes are perivascular cells that envelop and make intimate connections with adjacent capillary endothelial cells. Recent studies show that they may have a profound impact in skeletal muscle regeneration, innervation, vessel formation, fibrosis, fat accumulation, and ectopic bone formation throu...

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Autores principales: Birbrair, Alexander, Zhang, Tan, Wang, Zhong-Min, Messi, Maria L., Mintz, Akiva, Delbono, Osvaldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166895/
https://www.ncbi.nlm.nih.gov/pubmed/25278877
http://dx.doi.org/10.3389/fnagi.2014.00245
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author Birbrair, Alexander
Zhang, Tan
Wang, Zhong-Min
Messi, Maria L.
Mintz, Akiva
Delbono, Osvaldo
author_facet Birbrair, Alexander
Zhang, Tan
Wang, Zhong-Min
Messi, Maria L.
Mintz, Akiva
Delbono, Osvaldo
author_sort Birbrair, Alexander
collection PubMed
description Pericytes are perivascular cells that envelop and make intimate connections with adjacent capillary endothelial cells. Recent studies show that they may have a profound impact in skeletal muscle regeneration, innervation, vessel formation, fibrosis, fat accumulation, and ectopic bone formation throughout life. In this review, we summarize and evaluate recent advances in our understanding of pericytes' influence on adult skeletal muscle pathophysiology. We also discuss how further elucidating their biology may offer new approaches to the treatment of conditions characterized by muscle wasting.
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spelling pubmed-41668952014-10-02 Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle Birbrair, Alexander Zhang, Tan Wang, Zhong-Min Messi, Maria L. Mintz, Akiva Delbono, Osvaldo Front Aging Neurosci Neuroscience Pericytes are perivascular cells that envelop and make intimate connections with adjacent capillary endothelial cells. Recent studies show that they may have a profound impact in skeletal muscle regeneration, innervation, vessel formation, fibrosis, fat accumulation, and ectopic bone formation throughout life. In this review, we summarize and evaluate recent advances in our understanding of pericytes' influence on adult skeletal muscle pathophysiology. We also discuss how further elucidating their biology may offer new approaches to the treatment of conditions characterized by muscle wasting. Frontiers Media S.A. 2014-09-18 /pmc/articles/PMC4166895/ /pubmed/25278877 http://dx.doi.org/10.3389/fnagi.2014.00245 Text en Copyright © 2014 Birbrair, Zhang, Wang, Messi, Mintz and Delbono. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Birbrair, Alexander
Zhang, Tan
Wang, Zhong-Min
Messi, Maria L.
Mintz, Akiva
Delbono, Osvaldo
Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle
title Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle
title_full Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle
title_fullStr Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle
title_full_unstemmed Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle
title_short Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle
title_sort pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166895/
https://www.ncbi.nlm.nih.gov/pubmed/25278877
http://dx.doi.org/10.3389/fnagi.2014.00245
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