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Perturbation of Iron Homeostasis Promotes the Evolution of Antibiotic Resistance

Evolution of antibiotic resistance in microbes is frequently achieved by acquisition of spontaneous mutations during antimicrobial therapy. Here, we demonstrate that inactivation of a central transcriptional regulator of iron homeostasis (Fur) facilitates laboratory evolution of ciprofloxacin resist...

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Detalles Bibliográficos
Autores principales:	Méhi, Orsolya, Bogos, Balázs, Csörgő, Bálint, Pál, Ferenc, Nyerges, Ákos, Papp, Balázs, Pál, Csaba
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Discoveries
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166929/ https://www.ncbi.nlm.nih.gov/pubmed/25063442 http://dx.doi.org/10.1093/molbev/msu223

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