How to find RNA thermometers

Temperature is one of the decisive signals that a mammalian pathogen has entered its warm-blooded host. Among the many ways to register temperature changes, bacteria often use temperature-modulated structures in the untranslated region of mRNAs. In this article, we describe how such RNA thermometers...

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Detalles Bibliográficos
Autores principales: Righetti, Francesco, Narberhaus, Franz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166951/
https://www.ncbi.nlm.nih.gov/pubmed/25279353
http://dx.doi.org/10.3389/fcimb.2014.00132
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author Righetti, Francesco
Narberhaus, Franz
author_facet Righetti, Francesco
Narberhaus, Franz
author_sort Righetti, Francesco
collection PubMed
description Temperature is one of the decisive signals that a mammalian pathogen has entered its warm-blooded host. Among the many ways to register temperature changes, bacteria often use temperature-modulated structures in the untranslated region of mRNAs. In this article, we describe how such RNA thermometers (RNATs) have been discovered one by one upstream of heat shock and virulence genes in the past, and how next-generation sequencing approaches are able to reveal novel temperature-responsive RNA structures on a global scale.
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spelling pubmed-41669512014-10-02 How to find RNA thermometers Righetti, Francesco Narberhaus, Franz Front Cell Infect Microbiol Microbiology Temperature is one of the decisive signals that a mammalian pathogen has entered its warm-blooded host. Among the many ways to register temperature changes, bacteria often use temperature-modulated structures in the untranslated region of mRNAs. In this article, we describe how such RNA thermometers (RNATs) have been discovered one by one upstream of heat shock and virulence genes in the past, and how next-generation sequencing approaches are able to reveal novel temperature-responsive RNA structures on a global scale. Frontiers Media S.A. 2014-09-18 /pmc/articles/PMC4166951/ /pubmed/25279353 http://dx.doi.org/10.3389/fcimb.2014.00132 Text en Copyright © 2014 Righetti and Narberhaus. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Righetti, Francesco
Narberhaus, Franz
How to find RNA thermometers
title How to find RNA thermometers
title_full How to find RNA thermometers
title_fullStr How to find RNA thermometers
title_full_unstemmed How to find RNA thermometers
title_short How to find RNA thermometers
title_sort how to find rna thermometers
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166951/
https://www.ncbi.nlm.nih.gov/pubmed/25279353
http://dx.doi.org/10.3389/fcimb.2014.00132
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