Toward a Rationale for the PTC124 (Ataluren) Promoted Readthrough of Premature Stop Codons: A Computational Approach and GFP-Reporter Cell-Based Assay

[Image: see text] The presence in the mRNA of premature stop codons (PTCs) results in protein truncation responsible for several inherited (genetic) diseases. A well-known example of these diseases is cystic fibrosis (CF), where approximately 10% (worldwide) of patients have nonsense mutations in th...

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Detalles Bibliográficos
Autores principales: Lentini, Laura, Melfi, Raffaella, Di Leonardo, Aldo, Spinello, Angelo, Barone, Giampaolo, Pace, Andrea, Palumbo Piccionello, Antonio, Pibiri, Ivana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167060/
https://www.ncbi.nlm.nih.gov/pubmed/24483936
http://dx.doi.org/10.1021/mp400230s

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167060/
https://www.ncbi.nlm.nih.gov/pubmed/24483936
http://dx.doi.org/10.1021/mp400230s

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