Cargando…

Toward a Rationale for the PTC124 (Ataluren) Promoted Readthrough of Premature Stop Codons: A Computational Approach and GFP-Reporter Cell-Based Assay

[Image: see text] The presence in the mRNA of premature stop codons (PTCs) results in protein truncation responsible for several inherited (genetic) diseases. A well-known example of these diseases is cystic fibrosis (CF), where approximately 10% (worldwide) of patients have nonsense mutations in th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lentini, Laura, Melfi, Raffaella, Di Leonardo, Aldo, Spinello, Angelo, Barone, Giampaolo, Pace, Andrea, Palumbo Piccionello, Antonio, Pibiri, Ivana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167060/ https://www.ncbi.nlm.nih.gov/pubmed/24483936 http://dx.doi.org/10.1021/mp400230s

Ejemplares similares

Caffeine boosts Ataluren's readthrough activity
por: Lentini, Laura, et al.
Publicado: (2019)

Ataluren—Promising Therapeutic Premature Termination Codon Readthrough Frontrunner
por: Michorowska, Sylwia
Publicado: (2021)

A Lack of Premature Termination Codon Read-Through Efficacy of PTC124 (Ataluren) in a Diverse Array of Reporter Assays
por: McElroy, Stuart P., et al.
Publicado: (2013)

Strategies against Nonsense: Oxadiazoles as Translational Readthrough-Inducing Drugs (TRIDs)
por: Campofelice, Ambra, et al.
Publicado: (2019)

Readthrough Approach Using NV Translational Readthrough-Inducing Drugs (TRIDs): A Study of the Possible Off-Target Effects on Natural Termination Codons (NTCs) on TP53 and Housekeeping Gene Expression
por: Perriera, Riccardo, et al.
Publicado: (2023)

Heterologous Stop Codon Readthrough of Metazoan Readthrough Candidates in Yeast
por: Chan, Clara S., et al.
Publicado: (2013)

Aminoglycosides, but not PTC124 (Ataluren), rescue nonsense mutations in the leptin receptor and in luciferase reporter genes
por: Bolze, Florian, et al.
Publicado: (2017)

Evolutionary Dynamics of Abundant Stop Codon Readthrough
por: Jungreis, Irwin, et al.
Publicado: (2016)

A Simple and Affordable Method to Create Nonsense Mutation Clones of p53 for Studying the Premature Termination Codon Readthrough Activity of PTC124
por: Chen, Chia-Chi, et al.
Publicado: (2023)

Identification of stop codon readthrough genes in Saccharomyces cerevisiae
por: Namy, Olivier, et al.
Publicado: (2003)

Stop Codon Context-Specific Induction of Translational Readthrough
por: Schilff, Mirco, et al.
Publicado: (2021)

Evidence of efficient stop codon readthrough in four mammalian genes
por: Loughran, Gary, et al.
Publicado: (2014)

Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae
por: Mangkalaphiban, Kotchaphorn, et al.
Publicado: (2021)

Stop codon context influences genome-wide stimulation of termination codon readthrough by aminoglycosides
por: Wangen, Jamie R, et al.
Publicado: (2020)

Targeting Nonsense: Optimization of 1,2,4-Oxadiazole TRIDs to Rescue CFTR Expression and Functionality in Cystic Fibrosis Cell Model Systems
por: Pibiri, Ivana, et al.
Publicado: (2020)

A reporter system for translational readthrough of stop codons in human cells
por: Halvey, Patrick J., et al.
Publicado: (2012)

Pseudouridine-mediated stop codon readthrough in S. cerevisiae is sequence context–independent
por: Adachi, Hironori, et al.
Publicado: (2020)

Versatile Dual Reporter Gene Systems for Investigating Stop Codon Readthrough in Plants
por: Lao, Nga T., et al.
Publicado: (2009)

Translation initiation factor eIF3 promotes programmed stop codon readthrough
por: Beznosková, Petra, et al.
Publicado: (2015)

Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster
por: Dunn, Joshua G, et al.
Publicado: (2013)

Investigation of PTC124-mediated translational readthrough in a retinal organoid model of AIPL1-associated Leber congenital amaurosis
por: Leung, Amy, et al.
Publicado: (2022)

Stimulation of stop codon readthrough: frequent presence of an extended 3′ RNA structural element
por: Firth, Andrew E., et al.
Publicado: (2011)

Correction: Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster
por: Dunn, Joshua G, et al.
Publicado: (2014)

Stop codon readthrough contexts influence reporter expression differentially depending on the presence of an IRES
por: Yordanova, Martina M., et al.
Publicado: (2022)

Identification and functional characterization of mRNAs that exhibit stop codon readthrough in Arabidopsis thaliana
por: Sahoo, Sarthak, et al.
Publicado: (2022)

Genome-wide screening reveals metabolic regulation of stop-codon readthrough by cyclic AMP
por: Lyu, Zhihui, et al.
Publicado: (2023)

Investigating the Inhibition of FTSJ1, a Tryptophan tRNA-Specific 2′-O-Methyltransferase by NV TRIDs, as a Mechanism of Readthrough in Nonsense Mutated CFTR
por: Carollo, Pietro Salvatore, et al.
Publicado: (2023)

Analysis of Stop Codons within Prokaryotic Protein-Coding Genes Suggests Frequent Readthrough Events
por: Belinky, Frida, et al.
Publicado: (2021)

Modulation of Viral Programmed Ribosomal Frameshifting and Stop Codon Readthrough by the Host Restriction Factor Shiftless
por: Napthine, Sawsan, et al.
Publicado: (2021)

Investigating REPAIRv2 as a Tool to Edit CFTR mRNA with Premature Stop Codons
por: Melfi, Raffaella, et al.
Publicado: (2020)

Ataluren and aminoglycosides stimulate read-through of nonsense codons by orthogonal mechanisms
por: Ng, Martin Y., et al.
Publicado: (2021)

UAG readthrough in mammalian cells: Effect of upstream and downstream stop codon contexts reveal different signals
por: Cassan, Michel, et al.
Publicado: (2001)

Evaluation of Aminoglycoside and Non-Aminoglycoside Compounds for Stop-Codon Readthrough Therapy in Four Lysosomal Storage Diseases
por: Gómez-Grau, Marta, et al.
Publicado: (2015)

Stop codon readthrough alters the activity of a POU/Oct transcription factor during Drosophila development
por: Zhao, Yunpo, et al.
Publicado: (2021)

Recognition of 3′ nucleotide context and stop codon readthrough are determined during mRNA translation elongation
por: Biziaev, Nikita, et al.
Publicado: (2022)

Ataluren suppresses a premature termination codon in an MPS I-H mouse
por: Wang, Dan, et al.
Publicado: (2022)

Ribosomal Readthrough at a Short UGA Stop Codon Context Triggers Dual Localization of Metabolic Enzymes in Fungi and Animals
por: Stiebler, Alina C., et al.
Publicado: (2014)

The minor gentamicin complex component, X2, is a potent premature stop codon readthrough molecule with therapeutic potential
por: Friesen, Westley J., et al.
Publicado: (2018)

Increased expression of tryptophan and tyrosine tRNAs elevates stop codon readthrough of reporter systems in human cell lines
por: Beznosková, Petra, et al.
Publicado: (2021)

Properties of Non-Aminoglycoside Compounds Used to Stimulate Translational Readthrough of PTC Mutations in Primary Ciliary Dyskinesia
por: Dabrowski, Maciej, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_o7ose0d4hrb7rdk60je7c88fs5