Activity of crizotinib over choroidal metastases in Non-Small-Cell Lung Cancer (NSCLC)-ALK rearranged: a case report

BACKGROUND: Adenocarcinoma of the lung with EML4-ALK translocation is a rare subtype of Non Small-Cell Lung Cancer (NSCLC) that has recently shown to benefit from treatment with crizotinib. Despite the concerns about the efficacy of crizotinib over cerebral metastases, some reports have described it...

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Autores principales: Bearz, Alessandra, Santarossa, Sandra, Manfrè, Antonio, Beltrame, Giorgio, Urbani, Martina, Sartor, Ivana, Da Ros, Valentina, Tirelli, Umberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167132/
https://www.ncbi.nlm.nih.gov/pubmed/25178493
http://dx.doi.org/10.1186/1756-0500-7-589
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author Bearz, Alessandra
Santarossa, Sandra
Manfrè, Antonio
Beltrame, Giorgio
Urbani, Martina
Sartor, Ivana
Da Ros, Valentina
Tirelli, Umberto
author_facet Bearz, Alessandra
Santarossa, Sandra
Manfrè, Antonio
Beltrame, Giorgio
Urbani, Martina
Sartor, Ivana
Da Ros, Valentina
Tirelli, Umberto
author_sort Bearz, Alessandra
collection PubMed
description BACKGROUND: Adenocarcinoma of the lung with EML4-ALK translocation is a rare subtype of Non Small-Cell Lung Cancer (NSCLC) that has recently shown to benefit from treatment with crizotinib. Despite the concerns about the efficacy of crizotinib over cerebral metastases, some reports have described its activity, although always after local treatment with radiotherapy. Recently it has been reported activity of crizotinib over choroidal metastases, again after radiotherapy. CASE PRESENTATION: Herein we report a case of activity of crizotinib over choroidal metastases not previously treated with radiotherapy. CONCLUSION: We suggest crizotinib may be active over choroidal metastases in a patient harboring ALK translocation with no need of radiotherapy.
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spelling pubmed-41671322014-09-19 Activity of crizotinib over choroidal metastases in Non-Small-Cell Lung Cancer (NSCLC)-ALK rearranged: a case report Bearz, Alessandra Santarossa, Sandra Manfrè, Antonio Beltrame, Giorgio Urbani, Martina Sartor, Ivana Da Ros, Valentina Tirelli, Umberto BMC Res Notes Case Report BACKGROUND: Adenocarcinoma of the lung with EML4-ALK translocation is a rare subtype of Non Small-Cell Lung Cancer (NSCLC) that has recently shown to benefit from treatment with crizotinib. Despite the concerns about the efficacy of crizotinib over cerebral metastases, some reports have described its activity, although always after local treatment with radiotherapy. Recently it has been reported activity of crizotinib over choroidal metastases, again after radiotherapy. CASE PRESENTATION: Herein we report a case of activity of crizotinib over choroidal metastases not previously treated with radiotherapy. CONCLUSION: We suggest crizotinib may be active over choroidal metastases in a patient harboring ALK translocation with no need of radiotherapy. BioMed Central 2014-09-02 /pmc/articles/PMC4167132/ /pubmed/25178493 http://dx.doi.org/10.1186/1756-0500-7-589 Text en © Bearz et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Bearz, Alessandra
Santarossa, Sandra
Manfrè, Antonio
Beltrame, Giorgio
Urbani, Martina
Sartor, Ivana
Da Ros, Valentina
Tirelli, Umberto
Activity of crizotinib over choroidal metastases in Non-Small-Cell Lung Cancer (NSCLC)-ALK rearranged: a case report
title Activity of crizotinib over choroidal metastases in Non-Small-Cell Lung Cancer (NSCLC)-ALK rearranged: a case report
title_full Activity of crizotinib over choroidal metastases in Non-Small-Cell Lung Cancer (NSCLC)-ALK rearranged: a case report
title_fullStr Activity of crizotinib over choroidal metastases in Non-Small-Cell Lung Cancer (NSCLC)-ALK rearranged: a case report
title_full_unstemmed Activity of crizotinib over choroidal metastases in Non-Small-Cell Lung Cancer (NSCLC)-ALK rearranged: a case report
title_short Activity of crizotinib over choroidal metastases in Non-Small-Cell Lung Cancer (NSCLC)-ALK rearranged: a case report
title_sort activity of crizotinib over choroidal metastases in non-small-cell lung cancer (nsclc)-alk rearranged: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167132/
https://www.ncbi.nlm.nih.gov/pubmed/25178493
http://dx.doi.org/10.1186/1756-0500-7-589
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