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Greater frequency of CD5-negative CD8(+) T cells against human immunodeficiency virus type 1 than other viruses is consistent with adaptation to antigenic variation

BACKGROUND: The CD5 protein antagonizes phosphorylation events downstream of T cell receptor (TCR) engagement to decrease T cell responsiveness. CD5-negative T cell clones respond preferentially over their CD5(+) counterparts against cells with low human histocompatibility-linked leukocyte antigen (...

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Detalles Bibliográficos
Autores principales:	Penney, Stephen J, Gallant, Maureen E, Grant, Michael D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167305/ https://www.ncbi.nlm.nih.gov/pubmed/25237383 http://dx.doi.org/10.1186/1742-6405-11-30

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