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Are patients open to elective re-sampling of their glioblastoma? A new way of assessing treatment innovations
BACKGROUND: This is a qualitative study designed to examine patient acceptability of re-sampling surgery for glioblastoma multiforme (GBM) electively post-therapy or at asymptomatic relapse. METHODS: Thirty patients were selected using the convenience sampling method and interviewed. Patients were p...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Vienna
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167439/ https://www.ncbi.nlm.nih.gov/pubmed/25085543 http://dx.doi.org/10.1007/s00701-014-2189-3 |
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author | Mir, Taskia Dirks, Peter Mason, Warren P. Bernstein, Mark |
author_facet | Mir, Taskia Dirks, Peter Mason, Warren P. Bernstein, Mark |
author_sort | Mir, Taskia |
collection | PubMed |
description | BACKGROUND: This is a qualitative study designed to examine patient acceptability of re-sampling surgery for glioblastoma multiforme (GBM) electively post-therapy or at asymptomatic relapse. METHODS: Thirty patients were selected using the convenience sampling method and interviewed. Patients were presented with hypothetical scenarios including a scenario in which the surgery was offered to them routinely and a scenario in which the surgery was in a clinical trial. RESULTS: The results of the study suggest that about two thirds of the patients offered the surgery on a routine basis would be interested, and half of the patients would agree to the surgery as part of a clinical trial. Several overarching themes emerged, some of which include: patients expressed ethical concerns about offering financial incentives or compensation to the patients or surgeons involved in the study; patients were concerned about appropriate communication and full disclosure about the procedures involved, the legalities of tumor ownership and the use of the tumor post-surgery; patients may feel alone or vulnerable when they are approached about the surgery; patients and their families expressed immense trust in their surgeon and indicated that this trust is a major determinant of their agreeing to surgery. CONCLUSION: The overall positive response to re-sampling surgery suggests that this procedure, if designed with all the ethical concerns attended to, would be welcomed by most patients. This approach of asking patients beforehand if a treatment innovation is acceptable would appear to be more practical and ethically desirable than previous practice. |
format | Online Article Text |
id | pubmed-4167439 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-41674392014-09-22 Are patients open to elective re-sampling of their glioblastoma? A new way of assessing treatment innovations Mir, Taskia Dirks, Peter Mason, Warren P. Bernstein, Mark Acta Neurochir (Wien) Clinical Article - Brain Tumors BACKGROUND: This is a qualitative study designed to examine patient acceptability of re-sampling surgery for glioblastoma multiforme (GBM) electively post-therapy or at asymptomatic relapse. METHODS: Thirty patients were selected using the convenience sampling method and interviewed. Patients were presented with hypothetical scenarios including a scenario in which the surgery was offered to them routinely and a scenario in which the surgery was in a clinical trial. RESULTS: The results of the study suggest that about two thirds of the patients offered the surgery on a routine basis would be interested, and half of the patients would agree to the surgery as part of a clinical trial. Several overarching themes emerged, some of which include: patients expressed ethical concerns about offering financial incentives or compensation to the patients or surgeons involved in the study; patients were concerned about appropriate communication and full disclosure about the procedures involved, the legalities of tumor ownership and the use of the tumor post-surgery; patients may feel alone or vulnerable when they are approached about the surgery; patients and their families expressed immense trust in their surgeon and indicated that this trust is a major determinant of their agreeing to surgery. CONCLUSION: The overall positive response to re-sampling surgery suggests that this procedure, if designed with all the ethical concerns attended to, would be welcomed by most patients. This approach of asking patients beforehand if a treatment innovation is acceptable would appear to be more practical and ethically desirable than previous practice. Springer Vienna 2014-08-02 2014 /pmc/articles/PMC4167439/ /pubmed/25085543 http://dx.doi.org/10.1007/s00701-014-2189-3 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Clinical Article - Brain Tumors Mir, Taskia Dirks, Peter Mason, Warren P. Bernstein, Mark Are patients open to elective re-sampling of their glioblastoma? A new way of assessing treatment innovations |
title | Are patients open to elective re-sampling of their glioblastoma? A new way of assessing treatment innovations |
title_full | Are patients open to elective re-sampling of their glioblastoma? A new way of assessing treatment innovations |
title_fullStr | Are patients open to elective re-sampling of their glioblastoma? A new way of assessing treatment innovations |
title_full_unstemmed | Are patients open to elective re-sampling of their glioblastoma? A new way of assessing treatment innovations |
title_short | Are patients open to elective re-sampling of their glioblastoma? A new way of assessing treatment innovations |
title_sort | are patients open to elective re-sampling of their glioblastoma? a new way of assessing treatment innovations |
topic | Clinical Article - Brain Tumors |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167439/ https://www.ncbi.nlm.nih.gov/pubmed/25085543 http://dx.doi.org/10.1007/s00701-014-2189-3 |
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