Use of lithium in clozapine-induced neutropenia: a case report

BACKGROUND: The literature describing the long-term use of lithium carbonate to reinstate reduced levels of white blood cell counts in patients treated with clozapine is scarce. We describe a case of successful recommencement of clozapine on a patient who developed risk level of neutropenia which wa...

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Autores principales: Suraweera, Chathurie, Hanwella, Raveen, de Silva, Varuni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167504/
https://www.ncbi.nlm.nih.gov/pubmed/25214394
http://dx.doi.org/10.1186/1756-0500-7-635
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author Suraweera, Chathurie
Hanwella, Raveen
de Silva, Varuni
author_facet Suraweera, Chathurie
Hanwella, Raveen
de Silva, Varuni
author_sort Suraweera, Chathurie
collection PubMed
description BACKGROUND: The literature describing the long-term use of lithium carbonate to reinstate reduced levels of white blood cell counts in patients treated with clozapine is scarce. We describe a case of successful recommencement of clozapine on a patient who developed risk level of neutropenia which was corrected by lithium carbonate. He was followed up for a period of one year. CASE PRESENTATION: We report a 40-year-old Sri Lankan male who developed neutropenia and low white blood cell counts following commencement of clozapine. We were successful in restarting clozapine after the addition of lithium carbonate to increase the cell counts. Clozapine was increased to 700 mg a day with 500 mg of lithium carbonate. The patient remains stable after one year with no further episodes of neutropenia. CONCLUSION: Lithium carbonate can successfully be used to treat clozapine-induced neutropenia.
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spelling pubmed-41675042014-09-19 Use of lithium in clozapine-induced neutropenia: a case report Suraweera, Chathurie Hanwella, Raveen de Silva, Varuni BMC Res Notes Case Report BACKGROUND: The literature describing the long-term use of lithium carbonate to reinstate reduced levels of white blood cell counts in patients treated with clozapine is scarce. We describe a case of successful recommencement of clozapine on a patient who developed risk level of neutropenia which was corrected by lithium carbonate. He was followed up for a period of one year. CASE PRESENTATION: We report a 40-year-old Sri Lankan male who developed neutropenia and low white blood cell counts following commencement of clozapine. We were successful in restarting clozapine after the addition of lithium carbonate to increase the cell counts. Clozapine was increased to 700 mg a day with 500 mg of lithium carbonate. The patient remains stable after one year with no further episodes of neutropenia. CONCLUSION: Lithium carbonate can successfully be used to treat clozapine-induced neutropenia. BioMed Central 2014-09-12 /pmc/articles/PMC4167504/ /pubmed/25214394 http://dx.doi.org/10.1186/1756-0500-7-635 Text en © Suraweera et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Suraweera, Chathurie
Hanwella, Raveen
de Silva, Varuni
Use of lithium in clozapine-induced neutropenia: a case report
title Use of lithium in clozapine-induced neutropenia: a case report
title_full Use of lithium in clozapine-induced neutropenia: a case report
title_fullStr Use of lithium in clozapine-induced neutropenia: a case report
title_full_unstemmed Use of lithium in clozapine-induced neutropenia: a case report
title_short Use of lithium in clozapine-induced neutropenia: a case report
title_sort use of lithium in clozapine-induced neutropenia: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167504/
https://www.ncbi.nlm.nih.gov/pubmed/25214394
http://dx.doi.org/10.1186/1756-0500-7-635
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