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Tumor Microenvironmental Changes Induced by the Sulfamate Carbonic Anhydrase IX Inhibitor S4 in a Laryngeal Tumor Model

BACKGROUND AND PURPOSE: Carbonic anhydrase IX (CAIX) plays a pivotal role in pH homeostasis, which is essential for tumor cell survival. We examined the effect of the CAIX inhibitor 4-(3′(3″,5″-dimethylphenyl)-ureido)phenyl sulfamate (S4) on the tumor microenvironment in a laryngeal tumor model by a...

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Detalles Bibliográficos
Autores principales:	Meijer, Tineke W. H., Bussink, Johan, Zatovicova, Miriam, Span, Paul N., Lok, Jasper, Supuran, Claudiu T., Kaanders, Johannes H. A. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167542/ https://www.ncbi.nlm.nih.gov/pubmed/25225880 http://dx.doi.org/10.1371/journal.pone.0108068

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