Cargando…

Effects of Preoperative Intravenous Clonidine in Patients Undergoing Cataract Surgery: A Double-Blind, Randomized Trial

Objectives. The aim of this study was to assess the effects of clonidine on intraoperative analgesia, sedation, intraocular and blood pressure, arrhythmia, and ischemia. Methods. Forty patients undergoing cataract surgery were allocated into two groups. They were monitored with Holter machine, the p...

Descripción completa

Detalles Bibliográficos
Autores principales: Santiago, Ana Ellen Queiroz, Issy, Adriana Machado, Sakata, Rioko Kimiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167657/
https://www.ncbi.nlm.nih.gov/pubmed/25276415
http://dx.doi.org/10.1155/2014/346549
_version_ 1782335446487924736
author Santiago, Ana Ellen Queiroz
Issy, Adriana Machado
Sakata, Rioko Kimiko
author_facet Santiago, Ana Ellen Queiroz
Issy, Adriana Machado
Sakata, Rioko Kimiko
author_sort Santiago, Ana Ellen Queiroz
collection PubMed
description Objectives. The aim of this study was to assess the effects of clonidine on intraoperative analgesia, sedation, intraocular and blood pressure, arrhythmia, and ischemia. Methods. Forty patients undergoing cataract surgery were allocated into two groups. They were monitored with Holter machine, the pupil was dilated, and 30 minutes later, 20 patients received clonidine (4 µg/kg), while the other 20 patients were given a 0.9% saline intravenously. Twenty minutes later, 2% lidocaine gel was applied. There were assessed intraoperative analgesia, intraocular pressure, blood pressure, heart rate, and the occurrence of arrhythmias and myocardial ischemia. Results. Pain intensity was lower in G1 during the phacoemulsification, irrigation, aspiration, and intraocular lens implantation. The HR and BP were lower with clonidine. The IOP was lower with clonidine after 15 minutes and at the end of the surgery. Sedation was higher with clonidine. The incidence of arrhythmia was lower at the end of surgery with clonidine. The incidence of myocardial ischemia did not differ between the groups. Conclusions. Clonidine (4 µg/kg) before a phacoemulsification reduced the intensity of pain during cataract surgery. It also induced sedation, reduction of BP, HR, and incidence of arrhythmia at the end of the surgery, and did not alter myocardial ischemia. This trial is registered with Clinicaltrials.gov NCT01677351.
format Online
Article
Text
id pubmed-4167657
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-41676572014-09-28 Effects of Preoperative Intravenous Clonidine in Patients Undergoing Cataract Surgery: A Double-Blind, Randomized Trial Santiago, Ana Ellen Queiroz Issy, Adriana Machado Sakata, Rioko Kimiko J Ophthalmol Clinical Study Objectives. The aim of this study was to assess the effects of clonidine on intraoperative analgesia, sedation, intraocular and blood pressure, arrhythmia, and ischemia. Methods. Forty patients undergoing cataract surgery were allocated into two groups. They were monitored with Holter machine, the pupil was dilated, and 30 minutes later, 20 patients received clonidine (4 µg/kg), while the other 20 patients were given a 0.9% saline intravenously. Twenty minutes later, 2% lidocaine gel was applied. There were assessed intraoperative analgesia, intraocular pressure, blood pressure, heart rate, and the occurrence of arrhythmias and myocardial ischemia. Results. Pain intensity was lower in G1 during the phacoemulsification, irrigation, aspiration, and intraocular lens implantation. The HR and BP were lower with clonidine. The IOP was lower with clonidine after 15 minutes and at the end of the surgery. Sedation was higher with clonidine. The incidence of arrhythmia was lower at the end of surgery with clonidine. The incidence of myocardial ischemia did not differ between the groups. Conclusions. Clonidine (4 µg/kg) before a phacoemulsification reduced the intensity of pain during cataract surgery. It also induced sedation, reduction of BP, HR, and incidence of arrhythmia at the end of the surgery, and did not alter myocardial ischemia. This trial is registered with Clinicaltrials.gov NCT01677351. Hindawi Publishing Corporation 2014 2014-09-02 /pmc/articles/PMC4167657/ /pubmed/25276415 http://dx.doi.org/10.1155/2014/346549 Text en Copyright © 2014 Ana Ellen Queiroz Santiago et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Santiago, Ana Ellen Queiroz
Issy, Adriana Machado
Sakata, Rioko Kimiko
Effects of Preoperative Intravenous Clonidine in Patients Undergoing Cataract Surgery: A Double-Blind, Randomized Trial
title Effects of Preoperative Intravenous Clonidine in Patients Undergoing Cataract Surgery: A Double-Blind, Randomized Trial
title_full Effects of Preoperative Intravenous Clonidine in Patients Undergoing Cataract Surgery: A Double-Blind, Randomized Trial
title_fullStr Effects of Preoperative Intravenous Clonidine in Patients Undergoing Cataract Surgery: A Double-Blind, Randomized Trial
title_full_unstemmed Effects of Preoperative Intravenous Clonidine in Patients Undergoing Cataract Surgery: A Double-Blind, Randomized Trial
title_short Effects of Preoperative Intravenous Clonidine in Patients Undergoing Cataract Surgery: A Double-Blind, Randomized Trial
title_sort effects of preoperative intravenous clonidine in patients undergoing cataract surgery: a double-blind, randomized trial
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167657/
https://www.ncbi.nlm.nih.gov/pubmed/25276415
http://dx.doi.org/10.1155/2014/346549
work_keys_str_mv AT santiagoanaellenqueiroz effectsofpreoperativeintravenousclonidineinpatientsundergoingcataractsurgeryadoubleblindrandomizedtrial
AT issyadrianamachado effectsofpreoperativeintravenousclonidineinpatientsundergoingcataractsurgeryadoubleblindrandomizedtrial
AT sakatariokokimiko effectsofpreoperativeintravenousclonidineinpatientsundergoingcataractsurgeryadoubleblindrandomizedtrial