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Mechanical and In Vitro Biological Performance of Graphene Nanoplatelets Reinforced Calcium Silicate Composite

Calcium silicate (CaSiO(3), CS) ceramic composites reinforced with graphene nanoplatelets (GNP) were prepared using hot isostatic pressing (HIP) at 1150°C. Quantitative microstructural analysis suggests that GNP play a role in grain size and is responsible for the improved densification. Raman spect...

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Autores principales: Mehrali, Mehdi, Moghaddam, Ehsan, Seyed Shirazi, Seyed Farid, Baradaran, Saeid, Mehrali, Mohammad, Latibari, Sara Tahan, Metselaar, Hendrik Simon Cornelis, Kadri, Nahrizul Adib, Zandi, Keivan, Osman, Noor Azuan Abu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167702/
https://www.ncbi.nlm.nih.gov/pubmed/25229540
http://dx.doi.org/10.1371/journal.pone.0106802
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author Mehrali, Mehdi
Moghaddam, Ehsan
Seyed Shirazi, Seyed Farid
Baradaran, Saeid
Mehrali, Mohammad
Latibari, Sara Tahan
Metselaar, Hendrik Simon Cornelis
Kadri, Nahrizul Adib
Zandi, Keivan
Osman, Noor Azuan Abu
author_facet Mehrali, Mehdi
Moghaddam, Ehsan
Seyed Shirazi, Seyed Farid
Baradaran, Saeid
Mehrali, Mohammad
Latibari, Sara Tahan
Metselaar, Hendrik Simon Cornelis
Kadri, Nahrizul Adib
Zandi, Keivan
Osman, Noor Azuan Abu
author_sort Mehrali, Mehdi
collection PubMed
description Calcium silicate (CaSiO(3), CS) ceramic composites reinforced with graphene nanoplatelets (GNP) were prepared using hot isostatic pressing (HIP) at 1150°C. Quantitative microstructural analysis suggests that GNP play a role in grain size and is responsible for the improved densification. Raman spectroscopy and scanning electron microscopy showed that GNP survived the harsh processing conditions of the selected HIP processing parameters. The uniform distribution of 1 wt.% GNP in the CS matrix, high densification and fine CS grain size help to improve the fracture toughness by ∼130%, hardness by ∼30% and brittleness index by ∼40% as compared to the CS matrix without GNP. The toughening mechanisms, such as crack bridging, pull-out, branching and deflection induced by GNP are observed and discussed. The GNP/CS composites exhibit good apatite-forming ability in the simulated body fluid (SBF). Our results indicate that the addition of GNP decreased pH value in SBF. Effect of addition of GNP on early adhesion and proliferation of human osteoblast cells (hFOB) was measured in vitro. The GNP/CS composites showed good biocompatibility and promoted cell viability and cell proliferation. The results indicated that the cell viability and proliferation are affected by time and concentration of GNP in the CS matrix.
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spelling pubmed-41677022014-09-22 Mechanical and In Vitro Biological Performance of Graphene Nanoplatelets Reinforced Calcium Silicate Composite Mehrali, Mehdi Moghaddam, Ehsan Seyed Shirazi, Seyed Farid Baradaran, Saeid Mehrali, Mohammad Latibari, Sara Tahan Metselaar, Hendrik Simon Cornelis Kadri, Nahrizul Adib Zandi, Keivan Osman, Noor Azuan Abu PLoS One Research Article Calcium silicate (CaSiO(3), CS) ceramic composites reinforced with graphene nanoplatelets (GNP) were prepared using hot isostatic pressing (HIP) at 1150°C. Quantitative microstructural analysis suggests that GNP play a role in grain size and is responsible for the improved densification. Raman spectroscopy and scanning electron microscopy showed that GNP survived the harsh processing conditions of the selected HIP processing parameters. The uniform distribution of 1 wt.% GNP in the CS matrix, high densification and fine CS grain size help to improve the fracture toughness by ∼130%, hardness by ∼30% and brittleness index by ∼40% as compared to the CS matrix without GNP. The toughening mechanisms, such as crack bridging, pull-out, branching and deflection induced by GNP are observed and discussed. The GNP/CS composites exhibit good apatite-forming ability in the simulated body fluid (SBF). Our results indicate that the addition of GNP decreased pH value in SBF. Effect of addition of GNP on early adhesion and proliferation of human osteoblast cells (hFOB) was measured in vitro. The GNP/CS composites showed good biocompatibility and promoted cell viability and cell proliferation. The results indicated that the cell viability and proliferation are affected by time and concentration of GNP in the CS matrix. Public Library of Science 2014-09-17 /pmc/articles/PMC4167702/ /pubmed/25229540 http://dx.doi.org/10.1371/journal.pone.0106802 Text en © 2014 Mehrali et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Mehrali, Mehdi
Moghaddam, Ehsan
Seyed Shirazi, Seyed Farid
Baradaran, Saeid
Mehrali, Mohammad
Latibari, Sara Tahan
Metselaar, Hendrik Simon Cornelis
Kadri, Nahrizul Adib
Zandi, Keivan
Osman, Noor Azuan Abu
Mechanical and In Vitro Biological Performance of Graphene Nanoplatelets Reinforced Calcium Silicate Composite
title Mechanical and In Vitro Biological Performance of Graphene Nanoplatelets Reinforced Calcium Silicate Composite
title_full Mechanical and In Vitro Biological Performance of Graphene Nanoplatelets Reinforced Calcium Silicate Composite
title_fullStr Mechanical and In Vitro Biological Performance of Graphene Nanoplatelets Reinforced Calcium Silicate Composite
title_full_unstemmed Mechanical and In Vitro Biological Performance of Graphene Nanoplatelets Reinforced Calcium Silicate Composite
title_short Mechanical and In Vitro Biological Performance of Graphene Nanoplatelets Reinforced Calcium Silicate Composite
title_sort mechanical and in vitro biological performance of graphene nanoplatelets reinforced calcium silicate composite
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167702/
https://www.ncbi.nlm.nih.gov/pubmed/25229540
http://dx.doi.org/10.1371/journal.pone.0106802
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