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Saccharin Sulfonamides as Inhibitors of Carbonic Anhydrases I, II, VII, XII, and XIII

A series of modified saccharin sulfonamides have been designed as carbonic anhydrase (CA) inhibitors and synthesized. Their binding to CA isoforms I, II, VII, XII, and XIII was measured by the fluorescent thermal shift assay (FTSA) and isothermal titration calorimetry (ITC). Saccharin bound the CAs...

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Detalles Bibliográficos
Autores principales:	Morkūnaitė, Vaida, Baranauskienė, Lina, Zubrienė, Asta, Kairys, Visvaldas, Ivanova, Jekaterina, Trapencieris, Pēteris, Matulis, Daumantas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168026/ https://www.ncbi.nlm.nih.gov/pubmed/25276805 http://dx.doi.org/10.1155/2014/638902

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