Humanized TLR7/8 Expression Drives Proliferative Multisystemic Histiocytosis in C57BL/6 Mice

A humanized TLR7/TLR8 transgenic mouse line was engineered for studies using TLR7/8 ligands as vaccine adjuvants. The mice developed a spontaneous immune-mediated phenotype prior to six months of age characterized by runting, lethargy, blepharitis, and corneal ulceration. Histological examination re...

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Detalles Bibliográficos
Autores principales: Snyder, Jessica M., Treuting, Piper M., Nagy, Lee, Yam, Cathy, Yi, Jaehun, Brasfield, Alicia, Nguyen, Lisa Phuong Anh, Hajjar, Adeline M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168129/
https://www.ncbi.nlm.nih.gov/pubmed/25229618
http://dx.doi.org/10.1371/journal.pone.0107257

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