Cargando…
Cancer of the Prostate Risk Assessment (CAPRA) Preoperative Score Versus Postoperative Score (CAPRA-S): Ability to Predict Cancer Progression and Decision-Making Regarding Adjuvant Therapy after Radical Prostatectomy
The University of California, San Francisco, announced in 2011 Cancer of the Prostate Risk Assessment Postsurgical (CAPRA-S) score which included pathologic data, but there were no results for comparing preoperative predictors with the CAPRA-S score. We evaluated the validation of the CAPRA-S score...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168173/ https://www.ncbi.nlm.nih.gov/pubmed/25246738 http://dx.doi.org/10.3346/jkms.2014.29.9.1212 |
_version_ | 1782335504395534336 |
---|---|
author | Seo, Won Ik Kang, Pil Moon Kang, Dong Il Yoon, Jang Ho Kim, Wansuk Chung, Jae Il |
author_facet | Seo, Won Ik Kang, Pil Moon Kang, Dong Il Yoon, Jang Ho Kim, Wansuk Chung, Jae Il |
author_sort | Seo, Won Ik |
collection | PubMed |
description | The University of California, San Francisco, announced in 2011 Cancer of the Prostate Risk Assessment Postsurgical (CAPRA-S) score which included pathologic data, but there were no results for comparing preoperative predictors with the CAPRA-S score. We evaluated the validation of the CAPRA-S score in our institution and compare the result with the preoperative progression predictor, CAPRA score. Data of 130 patients were reviewed who underwent radical prostatectomy for localized prostate cancer from 2008 to 2013. Performance of CAPRA-S score in predicting progression free probabilities was assessed through Kaplan Meier analysis and Cox proportional hazards regression test. Additionally, prediction probability was compared with preoperative CAPRA score by logistic regression analysis. Comparing CAPRA score, the CAPRA-S score showed improved prediction ability for 5 yr progression free survival (concordance index 0.80, P = 0.04). After risk group stratification, 3 group model of CAPRA-S was superior than 3 group model of CAPRA for 3-yr progression free survival and 5-yr progression free survival (concordance index 0.74 vs. 0.70, 0.77 vs. 0.71, P < 0.001). Finally the CAPRA-S score was the more ideal predictor concerned with adjuvant therapy than the CAPRA score through decision curve analysis. The CPARA-S score is a useful predictor for disease progression after radical prostatectomy. GRAPHICAL ABSTRACT: [Image: see text] |
format | Online Article Text |
id | pubmed-4168173 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-41681732014-09-22 Cancer of the Prostate Risk Assessment (CAPRA) Preoperative Score Versus Postoperative Score (CAPRA-S): Ability to Predict Cancer Progression and Decision-Making Regarding Adjuvant Therapy after Radical Prostatectomy Seo, Won Ik Kang, Pil Moon Kang, Dong Il Yoon, Jang Ho Kim, Wansuk Chung, Jae Il J Korean Med Sci Original Article The University of California, San Francisco, announced in 2011 Cancer of the Prostate Risk Assessment Postsurgical (CAPRA-S) score which included pathologic data, but there were no results for comparing preoperative predictors with the CAPRA-S score. We evaluated the validation of the CAPRA-S score in our institution and compare the result with the preoperative progression predictor, CAPRA score. Data of 130 patients were reviewed who underwent radical prostatectomy for localized prostate cancer from 2008 to 2013. Performance of CAPRA-S score in predicting progression free probabilities was assessed through Kaplan Meier analysis and Cox proportional hazards regression test. Additionally, prediction probability was compared with preoperative CAPRA score by logistic regression analysis. Comparing CAPRA score, the CAPRA-S score showed improved prediction ability for 5 yr progression free survival (concordance index 0.80, P = 0.04). After risk group stratification, 3 group model of CAPRA-S was superior than 3 group model of CAPRA for 3-yr progression free survival and 5-yr progression free survival (concordance index 0.74 vs. 0.70, 0.77 vs. 0.71, P < 0.001). Finally the CAPRA-S score was the more ideal predictor concerned with adjuvant therapy than the CAPRA score through decision curve analysis. The CPARA-S score is a useful predictor for disease progression after radical prostatectomy. GRAPHICAL ABSTRACT: [Image: see text] The Korean Academy of Medical Sciences 2014-09 2014-09-02 /pmc/articles/PMC4168173/ /pubmed/25246738 http://dx.doi.org/10.3346/jkms.2014.29.9.1212 Text en © 2014 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Seo, Won Ik Kang, Pil Moon Kang, Dong Il Yoon, Jang Ho Kim, Wansuk Chung, Jae Il Cancer of the Prostate Risk Assessment (CAPRA) Preoperative Score Versus Postoperative Score (CAPRA-S): Ability to Predict Cancer Progression and Decision-Making Regarding Adjuvant Therapy after Radical Prostatectomy |
title | Cancer of the Prostate Risk Assessment (CAPRA) Preoperative Score Versus Postoperative Score (CAPRA-S): Ability to Predict Cancer Progression and Decision-Making Regarding Adjuvant Therapy after Radical Prostatectomy |
title_full | Cancer of the Prostate Risk Assessment (CAPRA) Preoperative Score Versus Postoperative Score (CAPRA-S): Ability to Predict Cancer Progression and Decision-Making Regarding Adjuvant Therapy after Radical Prostatectomy |
title_fullStr | Cancer of the Prostate Risk Assessment (CAPRA) Preoperative Score Versus Postoperative Score (CAPRA-S): Ability to Predict Cancer Progression and Decision-Making Regarding Adjuvant Therapy after Radical Prostatectomy |
title_full_unstemmed | Cancer of the Prostate Risk Assessment (CAPRA) Preoperative Score Versus Postoperative Score (CAPRA-S): Ability to Predict Cancer Progression and Decision-Making Regarding Adjuvant Therapy after Radical Prostatectomy |
title_short | Cancer of the Prostate Risk Assessment (CAPRA) Preoperative Score Versus Postoperative Score (CAPRA-S): Ability to Predict Cancer Progression and Decision-Making Regarding Adjuvant Therapy after Radical Prostatectomy |
title_sort | cancer of the prostate risk assessment (capra) preoperative score versus postoperative score (capra-s): ability to predict cancer progression and decision-making regarding adjuvant therapy after radical prostatectomy |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168173/ https://www.ncbi.nlm.nih.gov/pubmed/25246738 http://dx.doi.org/10.3346/jkms.2014.29.9.1212 |
work_keys_str_mv | AT seowonik canceroftheprostateriskassessmentcaprapreoperativescoreversuspostoperativescorecaprasabilitytopredictcancerprogressionanddecisionmakingregardingadjuvanttherapyafterradicalprostatectomy AT kangpilmoon canceroftheprostateriskassessmentcaprapreoperativescoreversuspostoperativescorecaprasabilitytopredictcancerprogressionanddecisionmakingregardingadjuvanttherapyafterradicalprostatectomy AT kangdongil canceroftheprostateriskassessmentcaprapreoperativescoreversuspostoperativescorecaprasabilitytopredictcancerprogressionanddecisionmakingregardingadjuvanttherapyafterradicalprostatectomy AT yoonjangho canceroftheprostateriskassessmentcaprapreoperativescoreversuspostoperativescorecaprasabilitytopredictcancerprogressionanddecisionmakingregardingadjuvanttherapyafterradicalprostatectomy AT kimwansuk canceroftheprostateriskassessmentcaprapreoperativescoreversuspostoperativescorecaprasabilitytopredictcancerprogressionanddecisionmakingregardingadjuvanttherapyafterradicalprostatectomy AT chungjaeil canceroftheprostateriskassessmentcaprapreoperativescoreversuspostoperativescorecaprasabilitytopredictcancerprogressionanddecisionmakingregardingadjuvanttherapyafterradicalprostatectomy |