Cargando…

Cancer of the Prostate Risk Assessment (CAPRA) Preoperative Score Versus Postoperative Score (CAPRA-S): Ability to Predict Cancer Progression and Decision-Making Regarding Adjuvant Therapy after Radical Prostatectomy

The University of California, San Francisco, announced in 2011 Cancer of the Prostate Risk Assessment Postsurgical (CAPRA-S) score which included pathologic data, but there were no results for comparing preoperative predictors with the CAPRA-S score. We evaluated the validation of the CAPRA-S score...

Descripción completa

Detalles Bibliográficos
Autores principales: Seo, Won Ik, Kang, Pil Moon, Kang, Dong Il, Yoon, Jang Ho, Kim, Wansuk, Chung, Jae Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168173/
https://www.ncbi.nlm.nih.gov/pubmed/25246738
http://dx.doi.org/10.3346/jkms.2014.29.9.1212
_version_ 1782335504395534336
author Seo, Won Ik
Kang, Pil Moon
Kang, Dong Il
Yoon, Jang Ho
Kim, Wansuk
Chung, Jae Il
author_facet Seo, Won Ik
Kang, Pil Moon
Kang, Dong Il
Yoon, Jang Ho
Kim, Wansuk
Chung, Jae Il
author_sort Seo, Won Ik
collection PubMed
description The University of California, San Francisco, announced in 2011 Cancer of the Prostate Risk Assessment Postsurgical (CAPRA-S) score which included pathologic data, but there were no results for comparing preoperative predictors with the CAPRA-S score. We evaluated the validation of the CAPRA-S score in our institution and compare the result with the preoperative progression predictor, CAPRA score. Data of 130 patients were reviewed who underwent radical prostatectomy for localized prostate cancer from 2008 to 2013. Performance of CAPRA-S score in predicting progression free probabilities was assessed through Kaplan Meier analysis and Cox proportional hazards regression test. Additionally, prediction probability was compared with preoperative CAPRA score by logistic regression analysis. Comparing CAPRA score, the CAPRA-S score showed improved prediction ability for 5 yr progression free survival (concordance index 0.80, P = 0.04). After risk group stratification, 3 group model of CAPRA-S was superior than 3 group model of CAPRA for 3-yr progression free survival and 5-yr progression free survival (concordance index 0.74 vs. 0.70, 0.77 vs. 0.71, P < 0.001). Finally the CAPRA-S score was the more ideal predictor concerned with adjuvant therapy than the CAPRA score through decision curve analysis. The CPARA-S score is a useful predictor for disease progression after radical prostatectomy. GRAPHICAL ABSTRACT: [Image: see text]
format Online
Article
Text
id pubmed-4168173
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher The Korean Academy of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-41681732014-09-22 Cancer of the Prostate Risk Assessment (CAPRA) Preoperative Score Versus Postoperative Score (CAPRA-S): Ability to Predict Cancer Progression and Decision-Making Regarding Adjuvant Therapy after Radical Prostatectomy Seo, Won Ik Kang, Pil Moon Kang, Dong Il Yoon, Jang Ho Kim, Wansuk Chung, Jae Il J Korean Med Sci Original Article The University of California, San Francisco, announced in 2011 Cancer of the Prostate Risk Assessment Postsurgical (CAPRA-S) score which included pathologic data, but there were no results for comparing preoperative predictors with the CAPRA-S score. We evaluated the validation of the CAPRA-S score in our institution and compare the result with the preoperative progression predictor, CAPRA score. Data of 130 patients were reviewed who underwent radical prostatectomy for localized prostate cancer from 2008 to 2013. Performance of CAPRA-S score in predicting progression free probabilities was assessed through Kaplan Meier analysis and Cox proportional hazards regression test. Additionally, prediction probability was compared with preoperative CAPRA score by logistic regression analysis. Comparing CAPRA score, the CAPRA-S score showed improved prediction ability for 5 yr progression free survival (concordance index 0.80, P = 0.04). After risk group stratification, 3 group model of CAPRA-S was superior than 3 group model of CAPRA for 3-yr progression free survival and 5-yr progression free survival (concordance index 0.74 vs. 0.70, 0.77 vs. 0.71, P < 0.001). Finally the CAPRA-S score was the more ideal predictor concerned with adjuvant therapy than the CAPRA score through decision curve analysis. The CPARA-S score is a useful predictor for disease progression after radical prostatectomy. GRAPHICAL ABSTRACT: [Image: see text] The Korean Academy of Medical Sciences 2014-09 2014-09-02 /pmc/articles/PMC4168173/ /pubmed/25246738 http://dx.doi.org/10.3346/jkms.2014.29.9.1212 Text en © 2014 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Seo, Won Ik
Kang, Pil Moon
Kang, Dong Il
Yoon, Jang Ho
Kim, Wansuk
Chung, Jae Il
Cancer of the Prostate Risk Assessment (CAPRA) Preoperative Score Versus Postoperative Score (CAPRA-S): Ability to Predict Cancer Progression and Decision-Making Regarding Adjuvant Therapy after Radical Prostatectomy
title Cancer of the Prostate Risk Assessment (CAPRA) Preoperative Score Versus Postoperative Score (CAPRA-S): Ability to Predict Cancer Progression and Decision-Making Regarding Adjuvant Therapy after Radical Prostatectomy
title_full Cancer of the Prostate Risk Assessment (CAPRA) Preoperative Score Versus Postoperative Score (CAPRA-S): Ability to Predict Cancer Progression and Decision-Making Regarding Adjuvant Therapy after Radical Prostatectomy
title_fullStr Cancer of the Prostate Risk Assessment (CAPRA) Preoperative Score Versus Postoperative Score (CAPRA-S): Ability to Predict Cancer Progression and Decision-Making Regarding Adjuvant Therapy after Radical Prostatectomy
title_full_unstemmed Cancer of the Prostate Risk Assessment (CAPRA) Preoperative Score Versus Postoperative Score (CAPRA-S): Ability to Predict Cancer Progression and Decision-Making Regarding Adjuvant Therapy after Radical Prostatectomy
title_short Cancer of the Prostate Risk Assessment (CAPRA) Preoperative Score Versus Postoperative Score (CAPRA-S): Ability to Predict Cancer Progression and Decision-Making Regarding Adjuvant Therapy after Radical Prostatectomy
title_sort cancer of the prostate risk assessment (capra) preoperative score versus postoperative score (capra-s): ability to predict cancer progression and decision-making regarding adjuvant therapy after radical prostatectomy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168173/
https://www.ncbi.nlm.nih.gov/pubmed/25246738
http://dx.doi.org/10.3346/jkms.2014.29.9.1212
work_keys_str_mv AT seowonik canceroftheprostateriskassessmentcaprapreoperativescoreversuspostoperativescorecaprasabilitytopredictcancerprogressionanddecisionmakingregardingadjuvanttherapyafterradicalprostatectomy
AT kangpilmoon canceroftheprostateriskassessmentcaprapreoperativescoreversuspostoperativescorecaprasabilitytopredictcancerprogressionanddecisionmakingregardingadjuvanttherapyafterradicalprostatectomy
AT kangdongil canceroftheprostateriskassessmentcaprapreoperativescoreversuspostoperativescorecaprasabilitytopredictcancerprogressionanddecisionmakingregardingadjuvanttherapyafterradicalprostatectomy
AT yoonjangho canceroftheprostateriskassessmentcaprapreoperativescoreversuspostoperativescorecaprasabilitytopredictcancerprogressionanddecisionmakingregardingadjuvanttherapyafterradicalprostatectomy
AT kimwansuk canceroftheprostateriskassessmentcaprapreoperativescoreversuspostoperativescorecaprasabilitytopredictcancerprogressionanddecisionmakingregardingadjuvanttherapyafterradicalprostatectomy
AT chungjaeil canceroftheprostateriskassessmentcaprapreoperativescoreversuspostoperativescorecaprasabilitytopredictcancerprogressionanddecisionmakingregardingadjuvanttherapyafterradicalprostatectomy