Cargando…

Anti-Müllerian Hormone Levels in the Follicular Fluid of the Preovulatory Follicle: A Predictor for Oocyte Fertilization and Quality of Embryo

This prospective study investigated the relationship between anti-Müllerian hormone (AMH) level in the follicular fluid (FF) and the quality of the oocyte and embryo. A total of 65 FF samples from 54 women were included in this study. FF was collected from the largest preovulatory follicle sized≥20...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Jee Hyun, Lee, Jung Ryeol, Chang, Hye Jin, Jee, Byung Chul, Suh, Chang Suk, Kim, Seok Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168181/
https://www.ncbi.nlm.nih.gov/pubmed/25246746
http://dx.doi.org/10.3346/jkms.2014.29.9.1266
_version_ 1782335506757976064
author Kim, Jee Hyun
Lee, Jung Ryeol
Chang, Hye Jin
Jee, Byung Chul
Suh, Chang Suk
Kim, Seok Hyun
author_facet Kim, Jee Hyun
Lee, Jung Ryeol
Chang, Hye Jin
Jee, Byung Chul
Suh, Chang Suk
Kim, Seok Hyun
author_sort Kim, Jee Hyun
collection PubMed
description This prospective study investigated the relationship between anti-Müllerian hormone (AMH) level in the follicular fluid (FF) and the quality of the oocyte and embryo. A total of 65 FF samples from 54 women were included in this study. FF was collected from the largest preovulatory follicle sized≥20 mm of mean diameter from each ovary. Samples were divided into 3 groups according to the FF AMH levels: below the 33th percentile (low group, FF AMH<2.1 ng/mL, n=21), between the 33th and the 67th percentile (intermediate group, FF AMH=2.1-3.6 ng/mL, n=22), and above the 67th percentile (high group, FF AMH>3.6 ng/mL, n=22). The quality of the ensuing oocytes and embryos was evaluated by fertilization rate and embryo score. FF AMH levels correlated positively with the matched embryo score on day 3 after fertilization (r=0.331, P=0.015). The normal fertilization rate was significantly lower in the low group than in the intermediate group (61.9% vs. 95.5% vs. 77.3%, respectively, P=0.028). Our results suggest that the FF AMH level could be a predictor of the ensuing oocyte and embryo quality. GRAPHICAL ABSTRACT: [Image: see text]
format Online
Article
Text
id pubmed-4168181
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher The Korean Academy of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-41681812014-09-22 Anti-Müllerian Hormone Levels in the Follicular Fluid of the Preovulatory Follicle: A Predictor for Oocyte Fertilization and Quality of Embryo Kim, Jee Hyun Lee, Jung Ryeol Chang, Hye Jin Jee, Byung Chul Suh, Chang Suk Kim, Seok Hyun J Korean Med Sci Original Article This prospective study investigated the relationship between anti-Müllerian hormone (AMH) level in the follicular fluid (FF) and the quality of the oocyte and embryo. A total of 65 FF samples from 54 women were included in this study. FF was collected from the largest preovulatory follicle sized≥20 mm of mean diameter from each ovary. Samples were divided into 3 groups according to the FF AMH levels: below the 33th percentile (low group, FF AMH<2.1 ng/mL, n=21), between the 33th and the 67th percentile (intermediate group, FF AMH=2.1-3.6 ng/mL, n=22), and above the 67th percentile (high group, FF AMH>3.6 ng/mL, n=22). The quality of the ensuing oocytes and embryos was evaluated by fertilization rate and embryo score. FF AMH levels correlated positively with the matched embryo score on day 3 after fertilization (r=0.331, P=0.015). The normal fertilization rate was significantly lower in the low group than in the intermediate group (61.9% vs. 95.5% vs. 77.3%, respectively, P=0.028). Our results suggest that the FF AMH level could be a predictor of the ensuing oocyte and embryo quality. GRAPHICAL ABSTRACT: [Image: see text] The Korean Academy of Medical Sciences 2014-09 2014-09-02 /pmc/articles/PMC4168181/ /pubmed/25246746 http://dx.doi.org/10.3346/jkms.2014.29.9.1266 Text en © 2014 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Jee Hyun
Lee, Jung Ryeol
Chang, Hye Jin
Jee, Byung Chul
Suh, Chang Suk
Kim, Seok Hyun
Anti-Müllerian Hormone Levels in the Follicular Fluid of the Preovulatory Follicle: A Predictor for Oocyte Fertilization and Quality of Embryo
title Anti-Müllerian Hormone Levels in the Follicular Fluid of the Preovulatory Follicle: A Predictor for Oocyte Fertilization and Quality of Embryo
title_full Anti-Müllerian Hormone Levels in the Follicular Fluid of the Preovulatory Follicle: A Predictor for Oocyte Fertilization and Quality of Embryo
title_fullStr Anti-Müllerian Hormone Levels in the Follicular Fluid of the Preovulatory Follicle: A Predictor for Oocyte Fertilization and Quality of Embryo
title_full_unstemmed Anti-Müllerian Hormone Levels in the Follicular Fluid of the Preovulatory Follicle: A Predictor for Oocyte Fertilization and Quality of Embryo
title_short Anti-Müllerian Hormone Levels in the Follicular Fluid of the Preovulatory Follicle: A Predictor for Oocyte Fertilization and Quality of Embryo
title_sort anti-müllerian hormone levels in the follicular fluid of the preovulatory follicle: a predictor for oocyte fertilization and quality of embryo
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168181/
https://www.ncbi.nlm.nih.gov/pubmed/25246746
http://dx.doi.org/10.3346/jkms.2014.29.9.1266
work_keys_str_mv AT kimjeehyun antimullerianhormonelevelsinthefollicularfluidofthepreovulatoryfollicleapredictorforoocytefertilizationandqualityofembryo
AT leejungryeol antimullerianhormonelevelsinthefollicularfluidofthepreovulatoryfollicleapredictorforoocytefertilizationandqualityofembryo
AT changhyejin antimullerianhormonelevelsinthefollicularfluidofthepreovulatoryfollicleapredictorforoocytefertilizationandqualityofembryo
AT jeebyungchul antimullerianhormonelevelsinthefollicularfluidofthepreovulatoryfollicleapredictorforoocytefertilizationandqualityofembryo
AT suhchangsuk antimullerianhormonelevelsinthefollicularfluidofthepreovulatoryfollicleapredictorforoocytefertilizationandqualityofembryo
AT kimseokhyun antimullerianhormonelevelsinthefollicularfluidofthepreovulatoryfollicleapredictorforoocytefertilizationandqualityofembryo