Cargando…

Biological activities of fusarochromanone: a potent anti-cancer agent

BACKGROUND: Fusarochromanone (FC101) is a small molecule fungal metabolite with a host of interesting biological functions, including very potent anti-angiogenic and direct anti-cancer activity. RESULTS: Herein, we report that FC101 exhibits very potent in-vitro growth inhibitory effects (IC(50) ran...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mahdavian, Elahe, Palyok, Phillip, Adelmund, Steven, Williams-Hart, Tara, Furmanski, Brian D, Kim, Yoon-Jee, Gu, Ying, Barzegar, Mansoureh, Wu, Yang, Bhinge, Kaustubh N, Kolluru, Gopi K, Quick, Quincy, Liu, Yong-Yu, Kevil, Christopher G, Salvatore, Brian A, Huang, Shile, Clifford, John L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168212/ https://www.ncbi.nlm.nih.gov/pubmed/25187308 http://dx.doi.org/10.1186/1756-0500-7-601

Ejemplares similares

Fusarochromanone Induces G(1) Cell Cycle Arrest and Apoptosis in COS7 and HEK293 Cells
por: Gu, Ying, et al.
Publicado: (2014)

Caspase-dependent signaling underlies glioblastoma cell death in response to the fungal metabolite, fusarochromanone
por: MAHDAVIAN, ELAHE, et al.
Publicado: (2014)

Fusarochromanone-induced reactive oxygen species results in activation of JNK cascade and cell death by inhibiting protein phosphatases 2A and 5
por: Gu, Ying, et al.
Publicado: (2015)

TNBC Therapeutics Based on Combination of Fusarochromanone with EGFR Inhibitors
por: Carroll, Natalie, et al.
Publicado: (2022)

Use of in-silico assays to characterize the ADMET profile and identify potential therapeutic targets of fusarochromanone, a novel anti-cancer agent
por: El-Saadi, Madison Wynne, et al.
Publicado: (2015)

It's a “Gut Feeling”: Association of Microbiota, Trimethylamine N‐Oxide and Cardiovascular Outcomes
por: Kolluru, Gopi K., et al.
Publicado: (2020)

A tale of two gases: NO and H(2)S, foes or friends for life?()
por: Kolluru, Gopi K., et al.
Publicado: (2013)

Reactive Sulfur Species: A New Redox Player in Cardiovascular Pathophysiology
por: Kolluru, Gopi K., et al.
Publicado: (2020)

Endothelial Dysfunction and Diabetes: Effects on Angiogenesis, Vascular Remodeling, and Wound Healing
por: Kolluru, Gopi Krishna, et al.
Publicado: (2012)

Sulfide regulation of cardiovascular function in health and disease
por: Kolluru, Gopi K., et al.
Publicado: (2022)

Nitrite Anion Therapy Protects Against Chronic Ischemic Tissue Injury in db/db Diabetic Mice in a NO/VEGF-Dependent Manner
por: Bir, Shyamal C., et al.
Publicado: (2014)

Maduramicin Inhibits Proliferation and Induces Apoptosis in Myoblast Cells
por: Chen, Xin, et al.
Publicado: (2014)

Hydrogen Sulfide Stimulates Ischemic Vascular Remodeling Through Nitric Oxide Synthase and Nitrite Reduction Activity Regulating Hypoxia‐Inducible Factor‐1α and Vascular Endothelial Growth Factor–Dependent Angiogenesis
por: Bir, Shyamal C., et al.
Publicado: (2012)

Hydrogen sulfide stimulates xanthine oxidoreductase conversion to nitrite reductase and formation of NO
por: Pardue, Sibile, et al.
Publicado: (2020)

Ciclopirox inhibits cancer cell proliferation by suppression of Cdc25A
por: Shen, Tao, et al.
Publicado: (2017)

VASCULAR ENDOTHELIAL GROWTH FACTOR IS ASSOCIATED WITH SEVERE COVID-19 DISEASE
por: Solorzano, Juan, et al.
Publicado: (2022)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

SGLT2 Inhibitors—A Medical Revelation: Molecular Signaling of Canagliflozin Underlying Hypertension and Vascular Remodeling
por: Yagi, Takashi, et al.
Publicado: (2022)

Microtubule-Actin Crosslinking Factor 1 and Plakins as Therapeutic Drug Targets
por: Quick, Quincy A.
Publicado: (2018)

Efficacy of PP121 in primary and metastatic non‑small cell lung cancers
por: Quick, Quincy A.
Publicado: (2023)

Decreased availability of nitric oxide and hydrogen sulfide is a hallmark of COVID-19
por: Dominic, Paari, et al.
Publicado: (2021)

Small Molecule, Big Prospects: MicroRNA in Pregnancy and Its Complications
por: Cai, Meng, et al.
Publicado: (2017)

Neurogranin regulates eNOS function and endothelial activation
por: Cheriyan, Vino T., et al.
Publicado: (2020)

Binding Studies of AICAR and Human Serum Albumin by Spectroscopic, Theoretical, and Computational Methodologies
por: Hashempour, Shokoufeh, et al.
Publicado: (2020)

Total sulfane sulfur bioavailability reflects ethnic and gender disparities in cardiovascular disease
por: Rajpal, Saurabh, et al.
Publicado: (2018)

SKLB188 inhibits the growth of head and neck squamous cell carcinoma by suppressing EGFR signalling
por: Barzegar, Mansoureh, et al.
Publicado: (2017)

Electrospun PVA Fibers for Drug Delivery: A Review
por: Zahra, Fatima T., et al.
Publicado: (2023)

1′-Acetoxychavicol acetate promotes caspase 3-activated glioblastoma cell death by overcoming enhanced cytokine expression
por: WILLIAMS, MUSA, et al.
Publicado: (2013)

Hypoxia increases persulfide and polysulfide formation by AMP kinase dependent cystathionine gamma lyase phosphorylation
por: Alam, Shafiul, et al.
Publicado: (2023)

Inhibition of the Spectraplakin Protein Microtubule Actin Crosslinking Factor 1 Sensitizes Glioblastomas to Radiation
por: Bonner, Kala, et al.
Publicado: (2020)

Thalidomide attenuates nitric oxide mediated angiogenesis by blocking migration of endothelial cells
por: Tamilarasan, KP, et al.
Publicado: (2006)

Decreased bioavailability of hydrogen sulfide links vascular endothelium and atrial remodeling in atrial fibrillation
por: Watts, Megan, et al.
Publicado: (2020)

Mitochondrial dysfunction and autophagy activation are associated with cardiomyopathy developed by extended methamphetamine self-administration in rats
por: Abdullah, Chowdhury S., et al.
Publicado: (2022)

Conserved multiepitope vaccine constructs: A potent HIV-1 therapeutic vaccine in clinical trials
por: Akbari, Elahe, et al.
Publicado: (2023)

Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and β-catenin signaling
por: Liu, Yong-Yu, et al.
Publicado: (2010)

Designing Potent Anticancer Peptides by Aurein 1.2 Key Residues Mutation and Catenate Cell-Penetrating Peptide
por: Salarpour Garnaie, Hamta, et al.
Publicado: (2023)

Methamphetamine causes cardiovascular dysfunction via cystathionine gamma lyase and hydrogen sulfide depletion
por: Kolluru, Gopi K., et al.
Publicado: (2022)

The Role of the ACE2/MasR Axis in Ischemic Stroke: New Insights for Therapy
por: Barzegar, Mansoureh, et al.
Publicado: (2021)

Novel oleogel formulation based on amaranth oil: Physicochemical characterization
por: Kamali, Elahe, et al.
Publicado: (2019)

Discovery of a novel potent peptide agonist to adiponectin receptor 1
por: Kim, Sunghwan, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_vsgbs9gpckriec8kei3egnrdit