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Perampanel Inhibition of AMPA Receptor Currents in Cultured Hippocampal Neurons
Perampanel is an aryl substituted 2-pyridone AMPA receptor antagonist that was recently approved as a treatment for epilepsy. The drug potently inhibits AMPA receptor responses but the mode of block has not been characterized. Here the action of perampanel on AMPA receptors was investigated by whole...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168215/ https://www.ncbi.nlm.nih.gov/pubmed/25229608 http://dx.doi.org/10.1371/journal.pone.0108021 |