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Perampanel Inhibition of AMPA Receptor Currents in Cultured Hippocampal Neurons

Perampanel is an aryl substituted 2-pyridone AMPA receptor antagonist that was recently approved as a treatment for epilepsy. The drug potently inhibits AMPA receptor responses but the mode of block has not been characterized. Here the action of perampanel on AMPA receptors was investigated by whole...

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Detalles Bibliográficos
Autores principales:	Chen, Chao-Yin, Matt, Lucas, Hell, Johannes Wilhelm, Rogawski, Michael A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168215/ https://www.ncbi.nlm.nih.gov/pubmed/25229608 http://dx.doi.org/10.1371/journal.pone.0108021

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