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Trypanosoma cruzi Infection and Host Lipid Metabolism
Trypanosoma cruzi is the causative agent of Chagas disease. Approximately 8 million people are thought to be affected worldwide. Several players in host lipid metabolism have been implicated in T. cruzi-host interactions in recent research, including macrophages, adipocytes, low density lipoprotein...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168237/ https://www.ncbi.nlm.nih.gov/pubmed/25276058 http://dx.doi.org/10.1155/2014/902038 |
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author | Miao, Qianqian Ndao, Momar |
author_facet | Miao, Qianqian Ndao, Momar |
author_sort | Miao, Qianqian |
collection | PubMed |
description | Trypanosoma cruzi is the causative agent of Chagas disease. Approximately 8 million people are thought to be affected worldwide. Several players in host lipid metabolism have been implicated in T. cruzi-host interactions in recent research, including macrophages, adipocytes, low density lipoprotein (LDL), low density lipoprotein receptor (LDLR), and high density lipoprotein (HDL). All of these factors are required to maintain host lipid homeostasis and are intricately connected via several metabolic pathways. We reviewed the interaction of T. cruzi with each of the relevant host components, in order to further understand the roles of host lipid metabolism in T. cruzi infection. This review sheds light on the potential impact of T. cruzi infection on the status of host lipid homeostasis. |
format | Online Article Text |
id | pubmed-4168237 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41682372014-09-28 Trypanosoma cruzi Infection and Host Lipid Metabolism Miao, Qianqian Ndao, Momar Mediators Inflamm Review Article Trypanosoma cruzi is the causative agent of Chagas disease. Approximately 8 million people are thought to be affected worldwide. Several players in host lipid metabolism have been implicated in T. cruzi-host interactions in recent research, including macrophages, adipocytes, low density lipoprotein (LDL), low density lipoprotein receptor (LDLR), and high density lipoprotein (HDL). All of these factors are required to maintain host lipid homeostasis and are intricately connected via several metabolic pathways. We reviewed the interaction of T. cruzi with each of the relevant host components, in order to further understand the roles of host lipid metabolism in T. cruzi infection. This review sheds light on the potential impact of T. cruzi infection on the status of host lipid homeostasis. Hindawi Publishing Corporation 2014 2014-09-03 /pmc/articles/PMC4168237/ /pubmed/25276058 http://dx.doi.org/10.1155/2014/902038 Text en Copyright © 2014 Q. Miao and M. Ndao. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Miao, Qianqian Ndao, Momar Trypanosoma cruzi Infection and Host Lipid Metabolism |
title |
Trypanosoma cruzi Infection and Host Lipid Metabolism |
title_full |
Trypanosoma cruzi Infection and Host Lipid Metabolism |
title_fullStr |
Trypanosoma cruzi Infection and Host Lipid Metabolism |
title_full_unstemmed |
Trypanosoma cruzi Infection and Host Lipid Metabolism |
title_short |
Trypanosoma cruzi Infection and Host Lipid Metabolism |
title_sort | trypanosoma cruzi infection and host lipid metabolism |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168237/ https://www.ncbi.nlm.nih.gov/pubmed/25276058 http://dx.doi.org/10.1155/2014/902038 |
work_keys_str_mv | AT miaoqianqian trypanosomacruziinfectionandhostlipidmetabolism AT ndaomomar trypanosomacruziinfectionandhostlipidmetabolism |