Mechanosensitive Kinases Regulate Stiffness-Induced Cardiomyocyte Maturation

Cells secrete and assemble extracellular matrix throughout development, giving rise to time-dependent, tissue-specific stiffness. Mimicking myocardial matrix stiffening, i.e. ~10-fold increase over 1 week, with a hydrogel system enhances myofibrillar organization of embryonic cardiomyocytes compared...

Descripción completa

Detalles Bibliográficos
Autores principales: Young, Jennifer L., Kretchmer, Kyle, Ondeck, Matthew G., Zambon, Alexander C., Engler, Adam J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168277/
https://www.ncbi.nlm.nih.gov/pubmed/25236849
http://dx.doi.org/10.1038/srep06425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168277/
https://www.ncbi.nlm.nih.gov/pubmed/25236849
http://dx.doi.org/10.1038/srep06425

Ejemplares similares