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Prevalence, nature and potential preventability of adverse drug events – a population-based medical record study of 4970 adults
AIMS: To estimate the 3 month prevalence of adverse drug events (ADEs), categories of ADEs and preventable ADEs, and the preventability of ADEs among adults in Sweden. Further, to identify drug classes and organ systems associated with ADEs and estimate their seriousness. METHODS: A random sample of...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Science Inc
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168391/ https://www.ncbi.nlm.nih.gov/pubmed/24372506 http://dx.doi.org/10.1111/bcp.12314 |
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author | Hakkarainen, Katja M Gyllensten, Hanna Jönsson, Anna K Andersson Sundell, Karolina Petzold, Max Hägg, Staffan |
author_facet | Hakkarainen, Katja M Gyllensten, Hanna Jönsson, Anna K Andersson Sundell, Karolina Petzold, Max Hägg, Staffan |
author_sort | Hakkarainen, Katja M |
collection | PubMed |
description | AIMS: To estimate the 3 month prevalence of adverse drug events (ADEs), categories of ADEs and preventable ADEs, and the preventability of ADEs among adults in Sweden. Further, to identify drug classes and organ systems associated with ADEs and estimate their seriousness. METHODS: A random sample of 5025 adults in a Swedish county council in 2008 was drawn from the Total Population Register. All their medical records in 29 inpatient care departments in three hospitals, 110 specialized outpatient clinics and 51 primary care units were reviewed retrospectively in a stepwise manner, and complemented with register data on dispensed drugs. ADEs, including adverse drug reactions (ADRs), sub-therapeutic effects of drug therapy (STEs), drug dependence and abuse, drug intoxications from overdose, and morbidities due to drug-related untreated indication, were detected during a 3 month study period, and assessed for preventability. RESULTS: Among 4970 included individuals, the prevalence of ADEs was 12.0% (95% confidence interval (CI) 11.1, 12.9%), and preventable ADEs 5.6% (95% CI 5.0, 6.2%). ADRs (6.9%; 95% CI 6.2, 7.6%) and STEs (6.4%; 95% CI 5.8, 7.1%) were more prevalent than the other ADEs. Of the ADEs, 38.8% (95% CI 35.8–41.9%) was preventable, varying by ADE category and seriousness. ADEs were frequently associated with nervous system and cardiovascular drugs, but the associated drugs and affected organs varied by ADE category. CONCLUSIONS: The considerable burden of ADEs and preventable ADEs from commonly used drugs across care settings warrants large-scale efforts to redesign safer, higher quality healthcare systems. The heterogeneous nature of the ADE categories should be considered in research and clinical practice for preventing, detecting and mitigating ADEs. |
format | Online Article Text |
id | pubmed-4168391 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Blackwell Science Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-41683912015-07-01 Prevalence, nature and potential preventability of adverse drug events – a population-based medical record study of 4970 adults Hakkarainen, Katja M Gyllensten, Hanna Jönsson, Anna K Andersson Sundell, Karolina Petzold, Max Hägg, Staffan Br J Clin Pharmacol Pharmacoepidemiology AIMS: To estimate the 3 month prevalence of adverse drug events (ADEs), categories of ADEs and preventable ADEs, and the preventability of ADEs among adults in Sweden. Further, to identify drug classes and organ systems associated with ADEs and estimate their seriousness. METHODS: A random sample of 5025 adults in a Swedish county council in 2008 was drawn from the Total Population Register. All their medical records in 29 inpatient care departments in three hospitals, 110 specialized outpatient clinics and 51 primary care units were reviewed retrospectively in a stepwise manner, and complemented with register data on dispensed drugs. ADEs, including adverse drug reactions (ADRs), sub-therapeutic effects of drug therapy (STEs), drug dependence and abuse, drug intoxications from overdose, and morbidities due to drug-related untreated indication, were detected during a 3 month study period, and assessed for preventability. RESULTS: Among 4970 included individuals, the prevalence of ADEs was 12.0% (95% confidence interval (CI) 11.1, 12.9%), and preventable ADEs 5.6% (95% CI 5.0, 6.2%). ADRs (6.9%; 95% CI 6.2, 7.6%) and STEs (6.4%; 95% CI 5.8, 7.1%) were more prevalent than the other ADEs. Of the ADEs, 38.8% (95% CI 35.8–41.9%) was preventable, varying by ADE category and seriousness. ADEs were frequently associated with nervous system and cardiovascular drugs, but the associated drugs and affected organs varied by ADE category. CONCLUSIONS: The considerable burden of ADEs and preventable ADEs from commonly used drugs across care settings warrants large-scale efforts to redesign safer, higher quality healthcare systems. The heterogeneous nature of the ADE categories should be considered in research and clinical practice for preventing, detecting and mitigating ADEs. Blackwell Science Inc 2014-07 2013-12-25 /pmc/articles/PMC4168391/ /pubmed/24372506 http://dx.doi.org/10.1111/bcp.12314 Text en © 2013 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of The British Pharmacological Society. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Pharmacoepidemiology Hakkarainen, Katja M Gyllensten, Hanna Jönsson, Anna K Andersson Sundell, Karolina Petzold, Max Hägg, Staffan Prevalence, nature and potential preventability of adverse drug events – a population-based medical record study of 4970 adults |
title | Prevalence, nature and potential preventability of adverse drug events – a population-based medical record study of 4970 adults |
title_full | Prevalence, nature and potential preventability of adverse drug events – a population-based medical record study of 4970 adults |
title_fullStr | Prevalence, nature and potential preventability of adverse drug events – a population-based medical record study of 4970 adults |
title_full_unstemmed | Prevalence, nature and potential preventability of adverse drug events – a population-based medical record study of 4970 adults |
title_short | Prevalence, nature and potential preventability of adverse drug events – a population-based medical record study of 4970 adults |
title_sort | prevalence, nature and potential preventability of adverse drug events – a population-based medical record study of 4970 adults |
topic | Pharmacoepidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168391/ https://www.ncbi.nlm.nih.gov/pubmed/24372506 http://dx.doi.org/10.1111/bcp.12314 |
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