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Using population isolates in genetic association studies

The use of genetically isolated populations can empower next-generation association studies. In this review, we discuss the advantages of this approach and review study design and analytical considerations of genetic association studies focusing on isolates. We cite successful examples of using popu...

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Detalles Bibliográficos
Autores principales: Hatzikotoulas, Konstantinos, Gilly, Arthur, Zeggini, Eleftheria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168662/
https://www.ncbi.nlm.nih.gov/pubmed/25009120
http://dx.doi.org/10.1093/bfgp/elu022
Descripción
Sumario:The use of genetically isolated populations can empower next-generation association studies. In this review, we discuss the advantages of this approach and review study design and analytical considerations of genetic association studies focusing on isolates. We cite successful examples of using population isolates in association studies and outline potential ways forward.