Using population isolates in genetic association studies

The use of genetically isolated populations can empower next-generation association studies. In this review, we discuss the advantages of this approach and review study design and analytical considerations of genetic association studies focusing on isolates. We cite successful examples of using popu...

Descripción completa

Detalles Bibliográficos
Autores principales: Hatzikotoulas, Konstantinos, Gilly, Arthur, Zeggini, Eleftheria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168662/
https://www.ncbi.nlm.nih.gov/pubmed/25009120
http://dx.doi.org/10.1093/bfgp/elu022
_version_ 1782335593009643520
author Hatzikotoulas, Konstantinos
Gilly, Arthur
Zeggini, Eleftheria
author_facet Hatzikotoulas, Konstantinos
Gilly, Arthur
Zeggini, Eleftheria
author_sort Hatzikotoulas, Konstantinos
collection PubMed
description The use of genetically isolated populations can empower next-generation association studies. In this review, we discuss the advantages of this approach and review study design and analytical considerations of genetic association studies focusing on isolates. We cite successful examples of using population isolates in association studies and outline potential ways forward.
format Online
Article
Text
id pubmed-4168662
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-41686622014-09-22 Using population isolates in genetic association studies Hatzikotoulas, Konstantinos Gilly, Arthur Zeggini, Eleftheria Brief Funct Genomics Papers The use of genetically isolated populations can empower next-generation association studies. In this review, we discuss the advantages of this approach and review study design and analytical considerations of genetic association studies focusing on isolates. We cite successful examples of using population isolates in association studies and outline potential ways forward. Oxford University Press 2014-09 2014-07-09 /pmc/articles/PMC4168662/ /pubmed/25009120 http://dx.doi.org/10.1093/bfgp/elu022 Text en © The Author 2014. Published by Oxford University Press. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Papers
Hatzikotoulas, Konstantinos
Gilly, Arthur
Zeggini, Eleftheria
Using population isolates in genetic association studies
title Using population isolates in genetic association studies
title_full Using population isolates in genetic association studies
title_fullStr Using population isolates in genetic association studies
title_full_unstemmed Using population isolates in genetic association studies
title_short Using population isolates in genetic association studies
title_sort using population isolates in genetic association studies
topic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168662/
https://www.ncbi.nlm.nih.gov/pubmed/25009120
http://dx.doi.org/10.1093/bfgp/elu022
work_keys_str_mv AT hatzikotoulaskonstantinos usingpopulationisolatesingeneticassociationstudies
AT gillyarthur usingpopulationisolatesingeneticassociationstudies
AT zegginieleftheria usingpopulationisolatesingeneticassociationstudies

Ejemplares similares