GeneMANIA: Fast gene network construction and function prediction for Cytoscape

The GeneMANIA Cytoscape app enables users to construct a composite gene-gene functional interaction network from a gene list. The resulting network includes the genes most related to the original list, and functional annotations from Gene Ontology. The edges are annotated with details about the publ...

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Detalles Bibliográficos
Autores principales: Montojo, Jason, Zuberi, Khalid, Rodriguez, Harold, Bader, Gary D., Morris, Quaid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2014
Materias:
Software Tool
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168749/
https://www.ncbi.nlm.nih.gov/pubmed/25254104
http://dx.doi.org/10.12688/f1000research.4572.1
Descripción
Sumario:The GeneMANIA Cytoscape app enables users to construct a composite gene-gene functional interaction network from a gene list. The resulting network includes the genes most related to the original list, and functional annotations from Gene Ontology. The edges are annotated with details about the publication or data source the interactions were derived from. The app leverages GeneMANIA’s database of 1800+ networks, containing over 500 million interactions spanning 8 organisms: A. thaliana, C. elegans, D. melanogaster, D. rerio, H. sapiens, M. musculus, R. norvegicus, and S. cerevisiae. Users may also import their own organisms, networks, and expression profiles. The app is compatible with Cytoscape versions 2 and 3.

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