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Copper(II)-Mediated O-Arylation of Protected Serines and Threonines
[Image: see text] An effective protocol toward the O-arylation of β-hydroxy-α-amino acid substrates serine and threonine has been developed via Chan–Lam cross-coupling. This Cu(II)-catalyzed transformation involves benign open-flask conditions that are well-tolerated with a variety of protected (Boc...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168772/ https://www.ncbi.nlm.nih.gov/pubmed/25208062 http://dx.doi.org/10.1021/ol5024689 |
| _version_ | 1782335615888523264 |
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| author | El Khatib, Mirna Molander, Gary A. |
| author_facet | El Khatib, Mirna Molander, Gary A. |
| author_sort | El Khatib, Mirna |
| collection | PubMed |
| description | [Image: see text] An effective protocol toward the O-arylation of β-hydroxy-α-amino acid substrates serine and threonine has been developed via Chan–Lam cross-coupling. This Cu(II)-catalyzed transformation involves benign open-flask conditions that are well-tolerated with a variety of protected (Boc-, Cbz-, Tr-, and Fmoc-) serine and threonine derivatives and various potassium organotrifluoroborates and boronic acids. |
| format | Online Article Text |
| id | pubmed-4168772 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| publisher | American
Chemical Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-41687722015-09-10 Copper(II)-Mediated O-Arylation of Protected Serines and Threonines El Khatib, Mirna Molander, Gary A. Org Lett [Image: see text] An effective protocol toward the O-arylation of β-hydroxy-α-amino acid substrates serine and threonine has been developed via Chan–Lam cross-coupling. This Cu(II)-catalyzed transformation involves benign open-flask conditions that are well-tolerated with a variety of protected (Boc-, Cbz-, Tr-, and Fmoc-) serine and threonine derivatives and various potassium organotrifluoroborates and boronic acids. American Chemical Society 2014-09-10 2014-09-19 /pmc/articles/PMC4168772/ /pubmed/25208062 http://dx.doi.org/10.1021/ol5024689 Text en Copyright © 2014 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) |
| spellingShingle | El Khatib, Mirna Molander, Gary A. Copper(II)-Mediated O-Arylation of Protected Serines and Threonines |
| title | Copper(II)-Mediated O-Arylation
of Protected Serines and Threonines |
| title_full | Copper(II)-Mediated O-Arylation
of Protected Serines and Threonines |
| title_fullStr | Copper(II)-Mediated O-Arylation
of Protected Serines and Threonines |
| title_full_unstemmed | Copper(II)-Mediated O-Arylation
of Protected Serines and Threonines |
| title_short | Copper(II)-Mediated O-Arylation
of Protected Serines and Threonines |
| title_sort | copper(ii)-mediated o-arylation
of protected serines and threonines |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168772/ https://www.ncbi.nlm.nih.gov/pubmed/25208062 http://dx.doi.org/10.1021/ol5024689 |
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