Oxazinin A, a Pseudodimeric Natural Product of Mixed Biosynthetic Origin from a Filamentous Fungus

[Image: see text] A racemic, prenylated polyketide dimer, oxazinin A (1), was isolated from a novel filamentous fungus in the class Eurotiomycetes, and its structure was elucidated spectroscopically. The pentacyclic structure of oxazinin A (1) is a unique combination of benzoxazine, isoquinoline, an...

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Autores principales: Lin, Zhenjian, Koch, Michael, Abdel Aziz, May Hamdy, Galindo-Murillo, Rodrigo, Tianero, Ma. Diarey, Cheatham, Thomas E., Barrows, Louis R., Reilly, Chris A., Schmidt, Eric W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168773/
https://www.ncbi.nlm.nih.gov/pubmed/25188821
http://dx.doi.org/10.1021/ol502227x
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author Lin, Zhenjian
Koch, Michael
Abdel Aziz, May Hamdy
Galindo-Murillo, Rodrigo
Tianero, Ma. Diarey
Cheatham, Thomas E.
Barrows, Louis R.
Reilly, Chris A.
Schmidt, Eric W.
author_facet Lin, Zhenjian
Koch, Michael
Abdel Aziz, May Hamdy
Galindo-Murillo, Rodrigo
Tianero, Ma. Diarey
Cheatham, Thomas E.
Barrows, Louis R.
Reilly, Chris A.
Schmidt, Eric W.
author_sort Lin, Zhenjian
collection PubMed
description [Image: see text] A racemic, prenylated polyketide dimer, oxazinin A (1), was isolated from a novel filamentous fungus in the class Eurotiomycetes, and its structure was elucidated spectroscopically. The pentacyclic structure of oxazinin A (1) is a unique combination of benzoxazine, isoquinoline, and a pyran ring. Oxazinin A (1) exhibited antimycobacterial activity and modestly antagonized transient receptor potential (TRP) channels.
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spelling pubmed-41687732015-09-04 Oxazinin A, a Pseudodimeric Natural Product of Mixed Biosynthetic Origin from a Filamentous Fungus Lin, Zhenjian Koch, Michael Abdel Aziz, May Hamdy Galindo-Murillo, Rodrigo Tianero, Ma. Diarey Cheatham, Thomas E. Barrows, Louis R. Reilly, Chris A. Schmidt, Eric W. Org Lett [Image: see text] A racemic, prenylated polyketide dimer, oxazinin A (1), was isolated from a novel filamentous fungus in the class Eurotiomycetes, and its structure was elucidated spectroscopically. The pentacyclic structure of oxazinin A (1) is a unique combination of benzoxazine, isoquinoline, and a pyran ring. Oxazinin A (1) exhibited antimycobacterial activity and modestly antagonized transient receptor potential (TRP) channels. American Chemical Society 2014-09-04 2014-09-19 /pmc/articles/PMC4168773/ /pubmed/25188821 http://dx.doi.org/10.1021/ol502227x Text en Copyright © 2014 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html)
spellingShingle Lin, Zhenjian
Koch, Michael
Abdel Aziz, May Hamdy
Galindo-Murillo, Rodrigo
Tianero, Ma. Diarey
Cheatham, Thomas E.
Barrows, Louis R.
Reilly, Chris A.
Schmidt, Eric W.
Oxazinin A, a Pseudodimeric Natural Product of Mixed Biosynthetic Origin from a Filamentous Fungus
title Oxazinin A, a Pseudodimeric Natural Product of Mixed Biosynthetic Origin from a Filamentous Fungus
title_full Oxazinin A, a Pseudodimeric Natural Product of Mixed Biosynthetic Origin from a Filamentous Fungus
title_fullStr Oxazinin A, a Pseudodimeric Natural Product of Mixed Biosynthetic Origin from a Filamentous Fungus
title_full_unstemmed Oxazinin A, a Pseudodimeric Natural Product of Mixed Biosynthetic Origin from a Filamentous Fungus
title_short Oxazinin A, a Pseudodimeric Natural Product of Mixed Biosynthetic Origin from a Filamentous Fungus
title_sort oxazinin a, a pseudodimeric natural product of mixed biosynthetic origin from a filamentous fungus
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168773/
https://www.ncbi.nlm.nih.gov/pubmed/25188821
http://dx.doi.org/10.1021/ol502227x
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