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Designed BH3 Peptides with High Affinity and Specificity for Targeting Mcl-1 in Cells
[Image: see text] Mcl-1 is overexpressed in many cancers and can confer resistance to cell-death signaling in refractory disease. Molecules that specifically inhibit Mcl-1 hold potential for diagnosing and disrupting Mcl-1-dependent cell survival. We selected three peptides from a yeast-surface disp...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168798/ https://www.ncbi.nlm.nih.gov/pubmed/25052212 http://dx.doi.org/10.1021/cb500340w |